MRP1 mediates folate transport and antifolate sensitivity in Plasmodium falciparum.
FEBS Lett
; 590(4): 482-92, 2016 Feb.
Article
em En
| MEDLINE
| ID: mdl-26900081
ABSTRACT
Multidrug resistance-associated proteins (MRP) of Plasmodium falciparum have been associated with altered drug sensitivity. Knowledge on MRP substrate specificity is indispensible for the characterization of resistance mechanisms and identifying its physiological roles. An untargeted metabolomics approach detected decreased folate concentrations in red blood cells infected with schizont stage parasites lacking expression of MRP1. Furthermore, a tenfold decrease in sensitivity toward the folate analog methotrexate was detected for parasites lacking MRP1. PfMRP1 is involved in the export of folate from parasites into red blood cells and is therefore a relevant factor for efficient malaria treatment through the folate pathway.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Plasmodium falciparum
/
Proteínas de Protozoários
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Resistência a Múltiplos Medicamentos
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Proteínas Associadas à Resistência a Múltiplos Medicamentos
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Ácido Fólico
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Antagonistas do Ácido Fólico
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Antimaláricos
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article