Lactosylceramide contributes to mitochondrial dysfunction in diabetes.

Novgorodov, Sergei A; Riley, Christopher L; Yu, Jin; Keffler, Jarryd A; Clarke, Christopher J; Van Laer, An O; Baicu, Catalin F; Zile, Michael R; Gudz, Tatyana I

Novgorodov, Sergei A; Riley, Christopher L; Yu, Jin; Keffler, Jarryd A; Clarke, Christopher J; Van Laer, An O; Baicu, Catalin F; Zile, Michael R; Gudz, Tatyana I.

Afiliação

Novgorodov SA; Departments of Neuroscience Medical University of South Carolina, Charleston, SC 29425 novgoros@musc.edu.
Riley CL; Ralph H. Johnson Veteran Affairs Medical Center, Charleston, SC 29401.
Yu J; Departments of Neuroscience Medical University of South Carolina, Charleston, SC 29425.
Keffler JA; Departments of Neuroscience Medical University of South Carolina, Charleston, SC 29425.
Clarke CJ; Department of Medicine, Stony Brook University, Stony Brook, NY 11794.
Van Laer AO; Ralph H. Johnson Veteran Affairs Medical Center, Charleston, SC 29401 Medicine, Medical University of South Carolina, Charleston, SC 29425.
Baicu CF; Ralph H. Johnson Veteran Affairs Medical Center, Charleston, SC 29401 Medicine, Medical University of South Carolina, Charleston, SC 29425.
Zile MR; Ralph H. Johnson Veteran Affairs Medical Center, Charleston, SC 29401 Medicine, Medical University of South Carolina, Charleston, SC 29425.
Gudz TI; Departments of Neuroscience Medical University of South Carolina, Charleston, SC 29425 Ralph H. Johnson Veteran Affairs Medical Center, Charleston, SC 29401.

J Lipid Res ; 57(4): 546-62, 2016 Apr.

Article em En | MEDLINE | ID: mdl-26900161

Assuntos

Diabetes Mellitus Tipo 1/metabolismo; Diabetes Mellitus Tipo 1/patologia; Lactosilceramidas/metabolismo; Mitocôndrias Cardíacas/metabolismo; Mitocôndrias Cardíacas/patologia; Animais; Respiração Celular; Diabetes Mellitus Tipo 1/enzimologia; Diabetes Mellitus Tipo 1/fisiopatologia; Regulação Enzimológica da Expressão Gênica; Técnicas de Silenciamento de Genes; Coração/fisiopatologia; Hidrólise; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Ceramidase Neutra/deficiência; Ceramidase Neutra/genética; Ceramidase Neutra/metabolismo

Palavras-chave

calcium; glycolipids; heart; mitochondria; respiration; sphingolipids

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 1 / Lactosilceramidas / Mitocôndrias Cardíacas Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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