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An EBV recombinant deleted for residues 130-159 in EBNA3C can deregulate p53/Mdm2 and Cyclin D1/CDK6 which results in apoptosis and reduced cell proliferation.
Shukla, Sanket Kumar; Jha, Hem Chandra; El-Naccache, Darine W; Robertson, Erle S.
Afiliação
  • Shukla SK; Department of Otorhinolaryngology and Tumor Virology Program, Abramson Cancer Center, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA-19104, USA.
  • Jha HC; Department of Otorhinolaryngology and Tumor Virology Program, Abramson Cancer Center, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA-19104, USA.
  • El-Naccache DW; Department of Otorhinolaryngology and Tumor Virology Program, Abramson Cancer Center, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA-19104, USA.
  • Robertson ES; Department of Otorhinolaryngology and Tumor Virology Program, Abramson Cancer Center, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA-19104, USA.
Oncotarget ; 7(14): 18116-34, 2016 Apr 05.
Article em En | MEDLINE | ID: mdl-26908453
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteína Supressora de Tumor p53 / Apoptose / Herpesvirus Humano 4 / Ciclina D1 / Proliferação de Células / Proteínas Proto-Oncogênicas c-mdm2 / Quinase 6 Dependente de Ciclina Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteína Supressora de Tumor p53 / Apoptose / Herpesvirus Humano 4 / Ciclina D1 / Proliferação de Células / Proteínas Proto-Oncogênicas c-mdm2 / Quinase 6 Dependente de Ciclina Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article