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Tumor MGMT promoter hypermethylation changes over time limit temozolomide efficacy in a phase II trial for metastatic colorectal cancer.
Amatu, A; Barault, L; Moutinho, C; Cassingena, A; Bencardino, K; Ghezzi, S; Palmeri, L; Bonazzina, E; Tosi, F; Ricotta, R; Cipani, T; Crivori, P; Gatto, R; Chirico, G; Marrapese, G; Truini, M; Bardelli, A; Esteller, M; Di Nicolantonio, F; Sartore-Bianchi, A; Siena, S.
Afiliação
  • Amatu A; Department of Hematology & Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan.
  • Barault L; Experimental Clinical Molecular Oncology Cancer Epigenetics, Candiolo Cancer Institute-FPO, IRCCS, Candiolo, Turin, Italy.
  • Moutinho C; Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.
  • Cassingena A; Department of Hematology & Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan.
  • Bencardino K; Department of Hematology & Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan.
  • Ghezzi S; Department of Hematology & Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan.
  • Palmeri L; Department of Hematology & Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan.
  • Bonazzina E; Department of Hematology & Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan.
  • Tosi F; Department of Hematology & Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan.
  • Ricotta R; Department of Hematology & Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan.
  • Cipani T; Department of Hematology & Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan.
  • Crivori P; Department of Oncology, CLIOSS s.r.l., Nerviano, Milan.
  • Gatto R; Department of Oncology, CLIOSS s.r.l., Nerviano, Milan.
  • Chirico G; Department of Hematology & Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan.
  • Marrapese G; Department of Hematology & Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan.
  • Truini M; Department of Hematology & Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan.
  • Bardelli A; Experimental Clinical Molecular Oncology Cancer Epigenetics, Candiolo Cancer Institute-FPO, IRCCS, Candiolo, Turin, Italy; Department of Oncology, University of Torino, Candiolo, Turin.
  • Esteller M; Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.
  • Di Nicolantonio F; Experimental Clinical Molecular Oncology Cancer Epigenetics, Candiolo Cancer Institute-FPO, IRCCS, Candiolo, Turin, Italy; Department of Oncology, University of Torino, Candiolo, Turin.
  • Sartore-Bianchi A; Department of Hematology & Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan. Electronic address: andrea.sartorebianchi@ospedaleniguarda.it.
  • Siena S; Department of Hematology & Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan; Department of Oncology, Università degli Studi di Milano, Milan, Italy.
Ann Oncol ; 27(6): 1062-1067, 2016 06.
Article em En | MEDLINE | ID: mdl-26916096
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Metilases de Modificação do DNA / Metilação de DNA / Proteínas Supressoras de Tumor / Dacarbazina / Enzimas Reparadoras do DNA Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Metilases de Modificação do DNA / Metilação de DNA / Proteínas Supressoras de Tumor / Dacarbazina / Enzimas Reparadoras do DNA Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article