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Anticancer activity studies of cubebin isolated from Piper cubeba and its synthetic derivatives.
Rajalekshmi, Dhanya S; Kabeer, Farha A; Madhusoodhanan, Arya R; Bahulayan, Arun K; Prathapan, Remani; Prakasan, Nisha; Varughese, Sunil; Nair, Mangalam S.
Afiliação
  • Rajalekshmi DS; Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram 695019, Kerala, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-NIIST, Thiruvananthapuram 695019, Kerala, India.
  • Kabeer FA; Division of Cancer Research, Regional Cancer Centre, Thiruvananthapuram, Kerala, India.
  • Madhusoodhanan AR; Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram 695019, Kerala, India.
  • Bahulayan AK; Agroprocessing and Natural Products Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram 695019, Kerala, India.
  • Prathapan R; Division of Cancer Research, Regional Cancer Centre, Thiruvananthapuram, Kerala, India.
  • Prakasan N; Agroprocessing and Natural Products Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram 695019, Kerala, India.
  • Varughese S; Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram 695019, Kerala, India.
  • Nair MS; Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram 695019, Kerala, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-NIIST, Thiruvananthapuram 695019, Kerala, India. Electronic address: msn555in@yahoo.c
Bioorg Med Chem Lett ; 26(7): 1767-71, 2016 Apr 01.
Article em En | MEDLINE | ID: mdl-26916436
(-)-Cubebin, isolated from the seeds of Piper cubeba, and its five different types of derivatives (a total of 17), with varying functionalities, were tested for their in vitro anticancer activity against six human cancer cell lines (A549, K562, SiHa, KB, HCT116 and HT29) using MTT assay. Cubebin as well as its derivatives containing lactone and amide groups showed significant anticancer activity. In some of the tested cell lines, the amide derivatives showed higher activity. Morphological analysis indicated that these compounds act through apoptosis mediated pathway of cell death and we expect that these results will pave new paths in the development of novel anticancer agents by the derivatization of (-)-cubebin.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Apoptose / Lignanas / Piper / Antineoplásicos Fitogênicos Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Apoptose / Lignanas / Piper / Antineoplásicos Fitogênicos Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article