Hedgehog Pathway Inhibition.
Cell
; 164(5): 831, 2016 Feb 25.
Article
em En
| MEDLINE
| ID: mdl-26919418
ABSTRACT
The hedgehog (Hh) signaling pathway is aberrantly activated in a majority of basal cell carcinomas (BCC). Vismodegib and sonidegib are targeted inhibitors of Smoothened (SMO). Both drugs are approved for use in locally advanced BCC (laBCC), with vismodegib also approved for metastatic BCC (mBCC).
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Piridinas
/
Neoplasias Cutâneas
/
Compostos de Bifenilo
/
Carcinoma Basocelular
/
Transdução de Sinais
/
Proteínas Hedgehog
/
Anilidas
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article