Vaccine effectiveness of PCV13 in a 3+1 vaccination schedule.
Vaccine
; 34(18): 2062-5, 2016 Apr 19.
Article
em En
| MEDLINE
| ID: mdl-26920471
ABSTRACT
OBJECTIVE:
To assess the vaccine effectiveness (VE) of PCV13 for invasive pneumococcal disease (IPD) regarding the extra six serotypes with a 3+1 schedule in Germany.METHODS:
Active surveillance for IPD in children <16 years eligible for PCV13 vaccination. We used the Broome method and logistic regression to estimate VE.RESULTS:
Data on 164/304 reported IPD cases were informative and met the inclusion criteria. VE for the extra six serotypes was 88% [95% confidence interval (CI) 73; 95] and 83% [56; 94] for at least one and for at least two doses respectively. VE for the complete 3+1 vaccination schedule was not conclusive because of a wide 95% CI. For serotype 3 VE appeared to be zero with an even wider 95% CI.CONCLUSION:
PCV13 VE against the extra six serotypes with the 3+1 schedule in Germany was only marginally higher compared to previously published data for the 2+1 schedule.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Infecções Pneumocócicas
/
Esquemas de Imunização
/
Vacinas Pneumocócicas
Tipo de estudo:
Screening_studies
Limite:
Child, preschool
/
Humans
/
Infant
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article