Transit of H2O2 across the endoplasmic reticulum membrane is not sluggish.
Free Radic Biol Med
; 94: 157-60, 2016 05.
Article
em En
| MEDLINE
| ID: mdl-26928585
ABSTRACT
Cellular metabolism provides various sources of hydrogen peroxide (H2O2) in different organelles and compartments. The suitability of H2O2 as an intracellular signaling molecule therefore also depends on its ability to pass cellular membranes. The propensity of the membranous boundary of the endoplasmic reticulum (ER) to let pass H2O2 has been discussed controversially. In this essay, we challenge the recent proposal that the ER membrane constitutes a simple barrier for H2O2 diffusion and support earlier data showing that (i) ample H2O2 permeability of the ER membrane is a prerequisite for signal transduction, (ii) aquaporin channels are crucially involved in the facilitation of H2O2 permeation, and (iii) a proper experimental framework not prone to artifacts is necessary to further unravel the role of H2O2 permeation in signal transduction and organelle biology.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Membrana Celular
/
Permeabilidade da Membrana Celular
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Retículo Endoplasmático
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Peróxido de Hidrogênio
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article