Design of an Os Complex-Modified Hydrogel with Optimized Redox Potential for Biosensors and Biofuel Cells.
Chemistry
; 22(15): 5319-26, 2016 Apr 04.
Article
em En
| MEDLINE
| ID: mdl-26929043
ABSTRACT
Multistep synthesis and electrochemical characterization of an Os complex-modified redox hydrogel exhibiting a redox potential ≈+30 mV (vs. Ag/AgCl 3 M KCl) is demonstrated. The careful selection of bipyridine-based ligands bearing N,N-dimethylamino moieties and an amino-linker for the covalent attachment to the polymer backbone ensures the formation of a stable redox polymer with an envisaged redox potential close to 0 V. Most importantly, the formation of an octahedral N6-coordination sphere around the Os central atoms provides improved stability concomitantly with the low formal potential, a low reorganization energy during the Os(3+/2+) redox conversion and a negligible impact on oxygen reduction. By wiring a variety of enzymes such as pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenase, flavin adenine dinucleotide (FAD)-dependent glucose dehydrogenase and the FAD-dependent dehydrogenase domain of cellobiose dehydrogenase, low-potential glucose biosensors could be obtained with negligible co-oxidation of common interfering compounds such as uric acid or ascorbic acid. In combination with a bilirubin oxidase-based biocathode, enzymatic biofuel cells with open-circuit voltages of up to 0.54 V were obtained.
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Base de dados:
MEDLINE
Assunto principal:
Osmio
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Desidrogenases de Carboidrato
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Hidrogel de Polietilenoglicol-Dimetacrilato
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Oxirredutases atuantes sobre Doadores de Grupo CH-CH
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Flavina-Adenina Dinucleotídeo
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Complexos de Coordenação
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Glucose Desidrogenase
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article