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Gray and white matter changes linking cerebral small vessel disease to gait disturbances.
Kim, Yeo Jin; Kwon, Hun Ki; Lee, Jong Min; Cho, Hanna; Kim, Hee Jin; Park, Hee Kyung; Jung, Na-Yeon; San Lee, Jin; Lee, Juyoun; Jang, Young Kyoung; Kim, Sung Tae; Lee, Kyung Han; Choe, Yearn Seong; Kim, Yun Joong; Na, Duk L; Seo, Sang Won.
Afiliação
  • Kim YJ; From the Department of Neurology (Y.J.K., H.J.K., N.-Y.J., J.S.L., J.L., Y.K.J., D.L.N., S.W.S.), Neuroscience Center (Y.J.K., H.J.K., N.-Y.J., J.S.L., J.L., Y.K.J., D.L.N., S.W.S.), and Nuclear Medicine (K.H.L., Y.S.C.), Samsung Medical Center, Sungkyunkwan University School of Medicine; Department
  • Kwon HK; From the Department of Neurology (Y.J.K., H.J.K., N.-Y.J., J.S.L., J.L., Y.K.J., D.L.N., S.W.S.), Neuroscience Center (Y.J.K., H.J.K., N.-Y.J., J.S.L., J.L., Y.K.J., D.L.N., S.W.S.), and Nuclear Medicine (K.H.L., Y.S.C.), Samsung Medical Center, Sungkyunkwan University School of Medicine; Department
  • Lee JM; From the Department of Neurology (Y.J.K., H.J.K., N.-Y.J., J.S.L., J.L., Y.K.J., D.L.N., S.W.S.), Neuroscience Center (Y.J.K., H.J.K., N.-Y.J., J.S.L., J.L., Y.K.J., D.L.N., S.W.S.), and Nuclear Medicine (K.H.L., Y.S.C.), Samsung Medical Center, Sungkyunkwan University School of Medicine; Department
  • Cho H; From the Department of Neurology (Y.J.K., H.J.K., N.-Y.J., J.S.L., J.L., Y.K.J., D.L.N., S.W.S.), Neuroscience Center (Y.J.K., H.J.K., N.-Y.J., J.S.L., J.L., Y.K.J., D.L.N., S.W.S.), and Nuclear Medicine (K.H.L., Y.S.C.), Samsung Medical Center, Sungkyunkwan University School of Medicine; Department
  • Kim HJ; From the Department of Neurology (Y.J.K., H.J.K., N.-Y.J., J.S.L., J.L., Y.K.J., D.L.N., S.W.S.), Neuroscience Center (Y.J.K., H.J.K., N.-Y.J., J.S.L., J.L., Y.K.J., D.L.N., S.W.S.), and Nuclear Medicine (K.H.L., Y.S.C.), Samsung Medical Center, Sungkyunkwan University School of Medicine; Department
  • Park HK; From the Department of Neurology (Y.J.K., H.J.K., N.-Y.J., J.S.L., J.L., Y.K.J., D.L.N., S.W.S.), Neuroscience Center (Y.J.K., H.J.K., N.-Y.J., J.S.L., J.L., Y.K.J., D.L.N., S.W.S.), and Nuclear Medicine (K.H.L., Y.S.C.), Samsung Medical Center, Sungkyunkwan University School of Medicine; Department
  • Jung NY; From the Department of Neurology (Y.J.K., H.J.K., N.-Y.J., J.S.L., J.L., Y.K.J., D.L.N., S.W.S.), Neuroscience Center (Y.J.K., H.J.K., N.-Y.J., J.S.L., J.L., Y.K.J., D.L.N., S.W.S.), and Nuclear Medicine (K.H.L., Y.S.C.), Samsung Medical Center, Sungkyunkwan University School of Medicine; Department
  • San Lee J; From the Department of Neurology (Y.J.K., H.J.K., N.-Y.J., J.S.L., J.L., Y.K.J., D.L.N., S.W.S.), Neuroscience Center (Y.J.K., H.J.K., N.-Y.J., J.S.L., J.L., Y.K.J., D.L.N., S.W.S.), and Nuclear Medicine (K.H.L., Y.S.C.), Samsung Medical Center, Sungkyunkwan University School of Medicine; Department
  • Lee J; From the Department of Neurology (Y.J.K., H.J.K., N.-Y.J., J.S.L., J.L., Y.K.J., D.L.N., S.W.S.), Neuroscience Center (Y.J.K., H.J.K., N.-Y.J., J.S.L., J.L., Y.K.J., D.L.N., S.W.S.), and Nuclear Medicine (K.H.L., Y.S.C.), Samsung Medical Center, Sungkyunkwan University School of Medicine; Department
  • Jang YK; From the Department of Neurology (Y.J.K., H.J.K., N.-Y.J., J.S.L., J.L., Y.K.J., D.L.N., S.W.S.), Neuroscience Center (Y.J.K., H.J.K., N.-Y.J., J.S.L., J.L., Y.K.J., D.L.N., S.W.S.), and Nuclear Medicine (K.H.L., Y.S.C.), Samsung Medical Center, Sungkyunkwan University School of Medicine; Department
  • Kim ST; From the Department of Neurology (Y.J.K., H.J.K., N.-Y.J., J.S.L., J.L., Y.K.J., D.L.N., S.W.S.), Neuroscience Center (Y.J.K., H.J.K., N.-Y.J., J.S.L., J.L., Y.K.J., D.L.N., S.W.S.), and Nuclear Medicine (K.H.L., Y.S.C.), Samsung Medical Center, Sungkyunkwan University School of Medicine; Department
  • Lee KH; From the Department of Neurology (Y.J.K., H.J.K., N.-Y.J., J.S.L., J.L., Y.K.J., D.L.N., S.W.S.), Neuroscience Center (Y.J.K., H.J.K., N.-Y.J., J.S.L., J.L., Y.K.J., D.L.N., S.W.S.), and Nuclear Medicine (K.H.L., Y.S.C.), Samsung Medical Center, Sungkyunkwan University School of Medicine; Department
  • Choe YS; From the Department of Neurology (Y.J.K., H.J.K., N.-Y.J., J.S.L., J.L., Y.K.J., D.L.N., S.W.S.), Neuroscience Center (Y.J.K., H.J.K., N.-Y.J., J.S.L., J.L., Y.K.J., D.L.N., S.W.S.), and Nuclear Medicine (K.H.L., Y.S.C.), Samsung Medical Center, Sungkyunkwan University School of Medicine; Department
  • Kim YJ; From the Department of Neurology (Y.J.K., H.J.K., N.-Y.J., J.S.L., J.L., Y.K.J., D.L.N., S.W.S.), Neuroscience Center (Y.J.K., H.J.K., N.-Y.J., J.S.L., J.L., Y.K.J., D.L.N., S.W.S.), and Nuclear Medicine (K.H.L., Y.S.C.), Samsung Medical Center, Sungkyunkwan University School of Medicine; Department
  • Na DL; From the Department of Neurology (Y.J.K., H.J.K., N.-Y.J., J.S.L., J.L., Y.K.J., D.L.N., S.W.S.), Neuroscience Center (Y.J.K., H.J.K., N.-Y.J., J.S.L., J.L., Y.K.J., D.L.N., S.W.S.), and Nuclear Medicine (K.H.L., Y.S.C.), Samsung Medical Center, Sungkyunkwan University School of Medicine; Department
  • Seo SW; From the Department of Neurology (Y.J.K., H.J.K., N.-Y.J., J.S.L., J.L., Y.K.J., D.L.N., S.W.S.), Neuroscience Center (Y.J.K., H.J.K., N.-Y.J., J.S.L., J.L., Y.K.J., D.L.N., S.W.S.), and Nuclear Medicine (K.H.L., Y.S.C.), Samsung Medical Center, Sungkyunkwan University School of Medicine; Department
Neurology ; 86(13): 1199-207, 2016 Mar 29.
Article em En | MEDLINE | ID: mdl-26935893
ABSTRACT

OBJECTIVE:

To investigate the topographic changes of white matter (WM) integrity and cortical thickness related to gait disturbances and determine whether these neural correlates mediate the association between cerebral small vessel disease (CSVD) and gait disturbances.

METHODS:

A total of 129 patients with subcortical vascular cognitive impairment were included. CSVD severity was quantified as global and regional WM hyperintensities (WMH) volume and lacune and microbleed numbers. Amyloid burdens were assessed using Pittsburgh compound B (PiB)-PET scanning. Gait score was measured using a standardized scale. WM integrity was assessed by applying tract-based spatial statistics. Cortical thickness was measured using surface-based methods. Path analysis for gait score was performed using regional CSVD markers as predictors and fractional anisotropy (FA) and cortical thickness as mediators.

RESULTS:

Periventricular WMH (PWMH) volume was associated with gait score, regardless of other CSVD. PiB retention ratio was not associated with gait score. Gait score was correlated with FA in the frontal and parietal WM and bilateral corpus callosum and with cortical thinning in the bilateral frontal and lateral temporo-parieto-occipital regions. Path analysis for gait score showed that PWMH contributed to gait disturbances with the mediation of mean FA or cortical thickness.

CONCLUSIONS:

Our findings suggest that WMH-related cortical thinning as well as disrupted integrity of periventricular WM is linked to gait disturbances.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtornos Neurológicos da Marcha / Doenças de Pequenos Vasos Cerebrais / Substância Cinzenta / Substância Branca Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtornos Neurológicos da Marcha / Doenças de Pequenos Vasos Cerebrais / Substância Cinzenta / Substância Branca Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male Idioma: En Ano de publicação: 2016 Tipo de documento: Article