An atom-efficient and convergent approach to the preparation of NS5A inhibitors by C-H activation.
Org Biomol Chem
; 14(12): 3307-13, 2016 Mar 28.
Article
em En
| MEDLINE
| ID: mdl-26936019
ABSTRACT
A novel approach of the convergent functionalisation of aryl dibromides to form NS5A type inhibitors using C-H activation is reported. The focus of investigation was to reduce the formation of homodimeric side product, as well as to investigate the scope of different aryl dibromides that were tolerated under the reaction conditions. The C-H activation methodology was found to give a viable synthetic route to NS5A inhibitors, with late stage functionalisation of the core portion of the molecule, albeit with some chemical functionalities not tolerated.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas não Estruturais Virais
/
Hidrocarbonetos Bromados
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article