[Relationship of MTHFR gene polymorphisms with infertility].
Zhonghua Nan Ke Xue
; 22(2): 171-4, 2016 Feb.
Article
em Zh
| MEDLINE
| ID: mdl-26939404
ABSTRACT
The folate metabolic pathway plays important roles in cellular physiology by participating in nucleotide synthesis, DNA repair and methylation, and maintenance and stability of the genome. Methylenetetrahydrofolate reductase (MTHFR) is a key regulatory enzyme involved in folate metabolism. Polymorphisms of MTHFR may change the level of homocysteine and affect DNA synthesis and methylation, leading to an increased oxidative stress and disturbed methylation reactions and consequently affecting reproductive function. This article presents an overview on MTHFR gene polymorphisms, proposing that multicentered, large-sample and long-term prospective studies are needed to reveal the relationship between MTHFR gene polymorphisms and infertility.
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Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Metilenotetra-Hidrofolato Redutase (NADPH2)
/
Infertilidade
Tipo de estudo:
Observational_studies
Limite:
Humans
Idioma:
Zh
Ano de publicação:
2016
Tipo de documento:
Article