Your browser doesn't support javascript.
loading
Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro.
Patin, Emmanuel C; Willcocks, Sam; Orr, Selinda; Ward, Theresa H; Lang, Roland; Schaible, Ulrich E.
Afiliação
  • Patin EC; Department of Immunology and Infection, Faculty of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, London, UK Priority Area Infections, Research Center Borstel, Borstel, Germany Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.
  • Willcocks S; Department of Immunology and Infection, Faculty of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, London, UK.
  • Orr S; Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.
  • Ward TH; Department of Immunology and Infection, Faculty of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, London, UK.
  • Lang R; Institute of Clinical Microbiology, Immunology and Hygiene, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
  • Schaible UE; Department of Immunology and Infection, Faculty of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, London, UK Priority Area Infections, Research Center Borstel, Borstel, Germany German Center for Infection Research, TTU-TB, Borstel, Germany uschaible@fz-borstel.de.
Innate Immun ; 22(3): 181-5, 2016 Apr.
Article em En | MEDLINE | ID: mdl-26939595
ABSTRACT
The role of macrophage-inducible C-type lectin (Mincle) in anti-inflammatory responses has not yet been fully characterized. Herein, we show that engagement of Mincle by trehalose-dimycolate or mycobacteria promotes IL-10 production in macrophages, which causes down-regulation of IL-12p40 secretion. Thus, Mincle mediates both pro- as well as anti-inflammatory responses.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tuberculose Pulmonar / Lectinas Tipo C / Macrófagos / Proteínas de Membrana / Mycobacteriaceae / Mycobacterium bovis Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tuberculose Pulmonar / Lectinas Tipo C / Macrófagos / Proteínas de Membrana / Mycobacteriaceae / Mycobacterium bovis Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article