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Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5'-C-Methyl Pyrimidine-Modified Oligonucleotides.
Kel'in, Alexander V; Zlatev, Ivan; Harp, Joel; Jayaraman, Muthusamy; Bisbe, Anna; O'Shea, Jonathan; Taneja, Nate; Manoharan, Rajar M; Khan, Saeed; Charisse, Klaus; Maier, Martin A; Egli, Martin; Rajeev, Kallanthottathil G; Manoharan, Muthiah.
Afiliação
  • Kel'in AV; Alnylam Pharmaceuticals , 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Zlatev I; Alnylam Pharmaceuticals , 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Harp J; Department of Biochemistry and Center for Structural Biology, Vanderbilt University, School of Medicine , Nashville, Tennessee 37232, United States.
  • Jayaraman M; Alnylam Pharmaceuticals , 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Bisbe A; Alnylam Pharmaceuticals , 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • O'Shea J; Alnylam Pharmaceuticals , 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Taneja N; Alnylam Pharmaceuticals , 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Manoharan RM; Alnylam Pharmaceuticals , 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Khan S; Department of Chemistry and Biochemistry, University of California , Los Angeles, California 90095, United States.
  • Charisse K; Alnylam Pharmaceuticals , 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Maier MA; Alnylam Pharmaceuticals , 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Egli M; Department of Biochemistry and Center for Structural Biology, Vanderbilt University, School of Medicine , Nashville, Tennessee 37232, United States.
  • Rajeev KG; Alnylam Pharmaceuticals , 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Manoharan M; Alnylam Pharmaceuticals , 300 Third Street, Cambridge, Massachusetts 02142, United States.
J Org Chem ; 81(6): 2261-79, 2016 Mar 18.
Article em En | MEDLINE | ID: mdl-26940174
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligonucleotídeos / Pirimidinas / Exorribonucleases Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligonucleotídeos / Pirimidinas / Exorribonucleases Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2016 Tipo de documento: Article