Kinetics genetics: Incorporating the concept of genomic balance into an understanding of quantitative traits.
Plant Sci
; 245: 128-34, 2016 Apr.
Article
em En
| MEDLINE
| ID: mdl-26940497
ABSTRACT
While most mutations are recessive, variants that affect quantitative traits are largely semi-dominant in their action making hybrids between divergent genotypes intermediate. In parallel, changes in chromosomal dosage (aneuploidy) for multiple regions of the genome modulate quantitative characters. We have previously argued that these observations are a reflection of a common process, originating from the more or less subtle effects of changes in dosage on the action of multi-subunit regulatory machineries. Kinetic analyses that vary the amount of one subunit of a complex while holding others constant do not always predict a linear response for the production of the whole. Indeed, in many instances, strong non-linear effects are expected. Here, we advocate that these kinetic observations and predictions should be incorporated into quantitative genetics thought.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Genoma de Planta
/
Característica Quantitativa Herdável
Tipo de estudo:
Prognostic_studies
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article