Determination of the total drug-related chlorine and bromine contents in human blood plasma using high performance liquid chromatography-tandem ICP-mass spectrometry (HPLC-ICP-MS/MS).

Klencsár, Balázs; Bolea-Fernandez, Eduardo; Flórez, María R; Balcaen, Lieve; Cuyckens, Filip; Lynen, Frederic; Vanhaecke, Frank

Klencsár, Balázs; Bolea-Fernandez, Eduardo; Flórez, María R; Balcaen, Lieve; Cuyckens, Filip; Lynen, Frederic; Vanhaecke, Frank.

Afiliação

Klencsár B; Ghent University, Department of Analytical Chemistry, Krijgslaan 281-S12, 9000 Ghent, Belgium.
Bolea-Fernandez E; Ghent University, Department of Analytical Chemistry, Krijgslaan 281-S12, 9000 Ghent, Belgium.
Flórez MR; Ghent University, Department of Analytical Chemistry, Krijgslaan 281-S12, 9000 Ghent, Belgium.
Balcaen L; Ghent University, Department of Analytical Chemistry, Krijgslaan 281-S12, 9000 Ghent, Belgium.
Cuyckens F; Janssen R&D, Pharmacokinetics, Dynamics & Metabolism, Turnhoutseweg 30, 2340 Beerse, Belgium.
Lynen F; Ghent University, Department of Organic and Macromolecular Chemistry, Krijgslaan 281-S4-bis, 9000 Ghent, Belgium.
Vanhaecke F; Ghent University, Department of Analytical Chemistry, Krijgslaan 281-S12, 9000 Ghent, Belgium. Electronic address: Frank.Vanhaecke@UGent.be.

J Pharm Biomed Anal ; 124: 112-119, 2016 May 30.

Article em En | MEDLINE | ID: mdl-26942335

Assuntos

Bromo/sangue; Cloro/sangue; Cromatografia Líquida de Alta Pressão/métodos; Espectrometria de Massas em Tandem/métodos; Humanos

Palavras-chave

Drug metabolism; Inductively coupled plasma; Total drug exposure; tandem mass spectrometry

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Bromo / Cloro / Cromatografia Líquida de Alta Pressão / Espectrometria de Massas em Tandem Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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