No Association Between CEL-HYB Hybrid Allele and Chronic Pancreatitis in Asian Populations.
Gastroenterology
; 150(7): 1558-1560.e5, 2016 06.
Article
em En
| MEDLINE
| ID: mdl-26946345
ABSTRACT
A hybrid allele between the carboxyl ester lipase gene (CEL) and its pseudogene, CELP (called CEL-HYB), generated by nonallelic homologous recombination between CEL intron 10 and CELP intron 10', was found to increase susceptibility to chronic pancreatitis in a case-control study of patients of European ancestry. We attempted to replicate this finding in 3 independent cohorts from China, Japan, and India, but failed to detect the CEL-HYB allele in any of these populations. The CEL-HYB allele might therefore be an ethnic-specific risk factor for chronic pancreatitis. An alternative hybrid allele (CEL-HYB2) was identified in all 3 Asian populations (1.7% combined carrier frequency), but was not associated with chronic pancreatitis.
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Base de dados:
MEDLINE
Assunto principal:
Pseudogenes
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Predisposição Genética para Doença
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Povo Asiático
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Pancreatite Crônica
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Lipase
Tipo de estudo:
Observational_studies
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Prognostic_studies
Limite:
Humans
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article