Design, syntheses, and anti-tuberculosis activities of conjugates of piperazino-1,3-benzothiazin-4-ones (pBTZs) with 2,7-dimethylimidazo [1,2-a]pyridine-3-carboxylic acids and 7-phenylacetyl cephalosporins.
Bioorg Med Chem Lett
; 26(8): 2068-71, 2016 Apr 15.
Article
em En
| MEDLINE
| ID: mdl-26951749
ABSTRACT
Tuberculosis (TB) remains one of the most threatening diseases in the world and the need for development of new therapies is dire. Herein we describe the rationale for the design and subsequent syntheses and studies of conjugates between pBTZ and both the imidazopyridine and cephalosporin scaffolds. Overall some compounds exhibited notable anti-TB activity in the range of 2-0.2 µM in the Microplate Alamar Blue (MABA) Assay.
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Base de dados:
MEDLINE
Assunto principal:
Piperazinas
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Piridinas
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Tiazinas
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Tuberculose
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Desenho de Fármacos
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Imidazóis
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Mycobacterium tuberculosis
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Antituberculosos
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article