Resting pulmonary artery pressure of 21-24â
mmHg predicts abnormal exercise haemodynamics.
Eur Respir J
; 47(5): 1436-44, 2016 05.
Article
em En
| MEDLINE
| ID: mdl-26965292
ABSTRACT
A resting mean pulmonary artery pressure (mPAP) of 21-24â
mmHg is above the upper limit of normal but does not reach criteria for the diagnosis of pulmonary hypertension (PH). We sought to determine whether an mPAP of 21-24â
mmHg is associated with an increased risk of developing an abnormal pulmonary vascular response during exercise.Consecutive patients (n=290) with resting mPAP <25â
mmHg who underwent invasive exercise haemodynamics were analysed. Risk factors for pulmonary vascular disease or left heart disease were present in 63.4% and 43.8% of subjects. An abnormal pulmonary vascular response (or exercise PH) was defined by mPAP >30â
mmHg and total pulmonary vascular resistance >3â
WU at maximal exercise.Exercise PH occurred in 74 (86.0%) out of 86 versus 96 (47.1%) out of 204 in the mPAP of 21-24â
mmHg and mPAP <21â
mmHg groups, respectively (OR 6.9, 95% CI 3.6-13.6; p<0.0001). Patients with mPAP of 21-24â
mmHg had lower 6-min walk distance (p=0.002) and higher New York Heart Association functional class status (p=0.03). Decreasing levels of mPAP were associated with a lower prevalence of exercise PH, which occurred in 60.3%, 38.7% and 7.7% of patients with mPAP of 17-20, 13-16 and <13â
mmHg, respectively.In an at-risk population, a resting mPAP between 21-24â
mmHg is closely associated with exercise PH together with worse functional capacity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Artéria Pulmonar
/
Exercício Físico
/
Hemodinâmica
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article