Rac1-PAK2 pathway is essential for zebrafish heart regeneration.
Biochem Biophys Res Commun
; 472(4): 637-42, 2016 Apr 15.
Article
em En
| MEDLINE
| ID: mdl-26966072
ABSTRACT
P-21 activated kinases, or PAKs, are serine-threonine kinases that play important roles in diverse heart functions include heart development, cardiovascular development and function in a range of models; however, the mechanisms by which PAKs mediate heart regeneration are unknown. Here, we demonstrate that PAK2 and PAK4 expression is induced in cardiomyocytes and vessels, respectively, following zebrafish heart injury. Inhibition of PAK2 and PAK4 using a specific small molecule inhibitor impedes cardiomyocyte proliferation/dedifferentiation and cardiovascular regeneration, respectively. Cdc42 is specifically expressed in the ventricle and may function upstream of PAK2 but not PAK4 under normal conditions and that cardiomyocyte proliferentation during heart regeneration relies on Rac1-mediated activation of Pak2. Our results indicate that PAKs play a key role in heart regeneration.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Regeneração
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Peixe-Zebra
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Transdução de Sinais
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Proteínas rac1 de Ligação ao GTP
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Proteínas de Peixe-Zebra
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Quinases Ativadas por p21
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Coração
Limite:
Animals
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article