Multiple modes of inhibition of human cytochrome P450 2J2 by dronedarone, amiodarone and their active metabolites.

Karkhanis, Aneesh; Lam, Hui Yuan; Venkatesan, Gopalakrishnan; Koh, Siew Kwan; Chai, Christina Li Lin; Zhou, Lei; Hong, Yanjun; Kojodjojo, Pipin; Chan, Eric Chun Yong

Karkhanis, Aneesh; Lam, Hui Yuan; Venkatesan, Gopalakrishnan; Koh, Siew Kwan; Chai, Christina Li Lin; Zhou, Lei; Hong, Yanjun; Kojodjojo, Pipin; Chan, Eric Chun Yong.

Afiliação

Karkhanis A; Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, Singapore 117543.
Lam HY; Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, Singapore 117543.
Venkatesan G; Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, Singapore 117543.
Koh SK; Singapore Eye Research Institute, The Academia, 20 College Road Discovery Tower Level 6, Singapore 169856.
Chai CL; Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, Singapore 117543.
Zhou L; Singapore Eye Research Institute, The Academia, 20 College Road Discovery Tower Level 6, Singapore 169856.
Hong Y; Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, Singapore 117543.
Kojodjojo P; Department of Cardiology and Cardiac Electrophysiology, National University Heart Centre, 5 Lower Kent Ridge Road, Singapore 119074.
Chan EC; Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, Singapore 117543. Electronic address: phaccye@nus.edu.sg.

Biochem Pharmacol ; 107: 67-80, 2016 May 01.

Article em En | MEDLINE | ID: mdl-26972388

Assuntos

Amiodarona/análogos & derivados; Amiodarona/farmacologia; Antiarrítmicos/farmacologia; Inibidores das Enzimas do Citocromo P-450/farmacologia; Sistema Enzimático do Citocromo P-450/metabolismo; Modelos Moleculares; Pró-Fármacos/farmacologia; Ativação Metabólica/efeitos dos fármacos; Amiodarona/química; Amiodarona/metabolismo; Animais; Antiarrítmicos/metabolismo; Linhagem Celular; Citocromo P-450 CYP2J2; Sistema Enzimático do Citocromo P-450/química; Sistema Enzimático do Citocromo P-450/genética; Descarboxilação/efeitos dos fármacos; Dronedarona; Humanos; Insetos; Cinética; Microssomos/efeitos dos fármacos; Microssomos/enzimologia; Estrutura Molecular; NADP/metabolismo; Oxirredução/efeitos dos fármacos; Pró-Fármacos/metabolismo; Proteínas Recombinantes/química; Proteínas Recombinantes/metabolismo; Especificidade por Substrato

Palavras-chave

Amiodarone; Amiodarone (PubChem CID: 2157); Amiodarone hydrochloride (PubChem CID: 441325); Astemizole (PubChem CID: 2247); Atrial fibrillation; CYP2J2; Danazol (PubChem CID: 28417); Dronedarone; Dronedarone (PubChem CID: 208898); Dronedarone hydrochloride (PubChem CID: 219025); Mechanism-based inactivation; N-desbutyldronedarone (PubChem CID: 10255437); N-desethylamiodarone (PubChem CID: 104774); Ritonavir (PubChem CID: 392622)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pró-Fármacos / Modelos Moleculares / Sistema Enzimático do Citocromo P-450 / Inibidores das Enzimas do Citocromo P-450 / Amiodarona / Antiarrítmicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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