Axin cancer mutants form nanoaggregates to rewire the Wnt signaling network.

Anvarian, Zeinab; Nojima, Hisashi; van Kappel, Eline C; Madl, Tobias; Spit, Maureen; Viertler, Martin; Jordens, Ingrid; Low, Teck Y; van Scherpenzeel, Revina C; Kuper, Ineke; Richter, Klaus; Heck, Albert J R; Boelens, Rolf; Vincent, Jean-Paul; Rüdiger, Stefan G D; Maurice, Madelon M

Anvarian, Zeinab; Nojima, Hisashi; van Kappel, Eline C; Madl, Tobias; Spit, Maureen; Viertler, Martin; Jordens, Ingrid; Low, Teck Y; van Scherpenzeel, Revina C; Kuper, Ineke; Richter, Klaus; Heck, Albert J R; Boelens, Rolf; Vincent, Jean-Paul; Rüdiger, Stefan G D; Maurice, Madelon M.

Afiliação

Anvarian Z; Department of Cell Biology, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands.
Nojima H; The Francis Crick Institute, Mill Hill, London, UK.
van Kappel EC; Department of Cell Biology, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands.
Madl T; NMR Spectroscopy Research Group, Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, the Netherlands.
Spit M; Institute of Structural Biology, Helmholtz Zentrum München, Neuherberg, Germany and Biomolecular NMR spectroscopy, Technische Universität München, Garching, Germany.
Viertler M; Institute of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
Jordens I; Omics Center Graz, BioTechMed Graz, Graz, Austria.
Low TY; Department of Cell Biology, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands.
van Scherpenzeel RC; Institute of Structural Biology, Helmholtz Zentrum München, Neuherberg, Germany and Biomolecular NMR spectroscopy, Technische Universität München, Garching, Germany.
Kuper I; Department of Cell Biology, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands.
Richter K; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands.
Heck AJ; The Netherlands Proteomics Center, Utrecht, the Netherlands.
Boelens R; Department of Cell Biology, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands.
Vincent JP; Department of Cell Biology, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands.
Rüdiger SG; Department of Chemistry, Technische Universität München, Garching, Germany.
Maurice MM; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands.

Nat Struct Mol Biol ; 23(4): 324-32, 2016 Apr.

Article em En | MEDLINE | ID: mdl-26974125

Assuntos

Proteína Axina/genética; Proteína Axina/metabolismo; Neoplasias/genética; Mutação Puntual; Agregados Proteicos; Via de Sinalização Wnt; Sequência de Aminoácidos; Animais; Proteína Axina/análise; Proteína Axina/ultraestrutura; Linhagem Celular; Drosophila/química; Drosophila/genética; Drosophila/metabolismo; Drosophila/ultraestrutura; Proteínas de Drosophila/análise; Proteínas de Drosophila/genética; Proteínas de Drosophila/metabolismo; Células HEK293; Humanos; Camundongos; Modelos Moleculares; Dados de Sequência Molecular; Mutação de Sentido Incorreto; Neoplasias/metabolismo; Neoplasias/patologia; Conformação Proteica; Mapas de Interação de Proteínas; Espalhamento a Baixo Ângulo; Alinhamento de Sequência; Difração de Raios X

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Mutação Puntual / Proteína Axina / Via de Sinalização Wnt / Agregados Proteicos / Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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