Stimulation of brain glucose uptake by cannabinoid CB2 receptors and its therapeutic potential in Alzheimer's disease.

Köfalvi, Attila; Lemos, Cristina; Martín-Moreno, Ana M; Pinheiro, Bárbara S; García-García, Luis; Pozo, Miguel A; Valério-Fernandes, Ângela; Beleza, Rui O; Agostinho, Paula; Rodrigues, Ricardo J; Pasquaré, Susana J; Cunha, Rodrigo A; de Ceballos, María L

Köfalvi, Attila; Lemos, Cristina; Martín-Moreno, Ana M; Pinheiro, Bárbara S; García-García, Luis; Pozo, Miguel A; Valério-Fernandes, Ângela; Beleza, Rui O; Agostinho, Paula; Rodrigues, Ricardo J; Pasquaré, Susana J; Cunha, Rodrigo A; de Ceballos, María L.

Afiliação

Köfalvi A; CNC - Center for Neuroscience and Cell Biology of Coimbra, University of Coimbra, 3004-504 Coimbra, Portugal; Institute for Interdisciplinary Research, University of Coimbra, Coimbra, Portugal.
Lemos C; CNC - Center for Neuroscience and Cell Biology of Coimbra, University of Coimbra, 3004-504 Coimbra, Portugal.
Martín-Moreno AM; Neurodegeneration Group, Department of Cellular, Molecular and Developmental Neurobiology, Instituto Cajal, CSIC, Doctor Arce, 37, 28002 Madrid, Spain; CIBERNED; Centre for Biomedical Research on Neurodegenerative Diseases, Spain.
Pinheiro BS; CNC - Center for Neuroscience and Cell Biology of Coimbra, University of Coimbra, 3004-504 Coimbra, Portugal.
García-García L; CAI de Cartografía Cerebral, Instituto Pluridisciplinar, UCM, Madrid, Spain.
Pozo MA; CAI de Cartografía Cerebral, Instituto Pluridisciplinar, UCM, Madrid, Spain; PET Technology Institute, Madrid, Spain.
Valério-Fernandes Â; CNC - Center for Neuroscience and Cell Biology of Coimbra, University of Coimbra, 3004-504 Coimbra, Portugal.
Beleza RO; CNC - Center for Neuroscience and Cell Biology of Coimbra, University of Coimbra, 3004-504 Coimbra, Portugal.
Agostinho P; CNC - Center for Neuroscience and Cell Biology of Coimbra, University of Coimbra, 3004-504 Coimbra, Portugal; FMUC, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Rodrigues RJ; CNC - Center for Neuroscience and Cell Biology of Coimbra, University of Coimbra, 3004-504 Coimbra, Portugal; Institute for Interdisciplinary Research, University of Coimbra, Coimbra, Portugal.
Pasquaré SJ; Neurodegeneration Group, Department of Cellular, Molecular and Developmental Neurobiology, Instituto Cajal, CSIC, Doctor Arce, 37, 28002 Madrid, Spain; Instituto de Investigaciones Bioquímicas de Bahía Blanca (INIBIBB), CONICET-Bahía Blanca and Universidad Nacional del Sur, Edificio E1, Camino La Ca
Cunha RA; CNC - Center for Neuroscience and Cell Biology of Coimbra, University of Coimbra, 3004-504 Coimbra, Portugal; FMUC, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
de Ceballos ML; Neurodegeneration Group, Department of Cellular, Molecular and Developmental Neurobiology, Instituto Cajal, CSIC, Doctor Arce, 37, 28002 Madrid, Spain; CIBERNED; Centre for Biomedical Research on Neurodegenerative Diseases, Spain. Electronic address: mceballos@cajal.csic.es.

Neuropharmacology ; 110(Pt A): 519-529, 2016 11.

Article em En | MEDLINE | ID: mdl-26976670

Assuntos

Doença de Alzheimer/metabolismo; Encéfalo/metabolismo; Glucose/metabolismo; Receptor CB2 de Canabinoide/metabolismo; Envelhecimento/efeitos dos fármacos; Envelhecimento/metabolismo; Doença de Alzheimer/diagnóstico por imagem; Doença de Alzheimer/tratamento farmacológico; Precursor de Proteína beta-Amiloide; Amiloidose/diagnóstico por imagem; Amiloidose/tratamento farmacológico; Amiloidose/metabolismo; Animais; Ácidos Araquidônicos/metabolismo; Astrócitos/efeitos dos fármacos; Astrócitos/metabolismo; Encéfalo/diagnóstico por imagem; Encéfalo/efeitos dos fármacos; Moduladores de Receptores de Canabinoides/farmacologia; Células Cultivadas; Ciclo-Oxigenase 2/metabolismo; Inibidores de Ciclo-Oxigenase 2/farmacologia; Endocanabinoides/metabolismo; Hidroxietilrutosídeo; Masculino; Camundongos Endogâmicos C57BL; Camundongos Transgênicos; Neurônios/efeitos dos fármacos; Neurônios/metabolismo; Nootrópicos/farmacologia; Alcamidas Poli-Insaturadas/metabolismo; Receptor CB2 de Canabinoide/agonistas; Receptor CB2 de Canabinoide/antagonistas & inibidores; Técnicas de Cultura de Tecidos

Palavras-chave

10252734); 108223); 11507802); 2-Arachidonoylglycerol (PubChem CID; 2-Deoxy-d-glucose (PubChem CID; 25021165); 3177); 4302963); 439501); 5281969); 5282280); 5311006); 5311501); 6918505); AM630 (PubChem CID; Anandamide (AEA); Anandamide (PubChem CID; Arachidonyl-2-chloroethylamide (PubChem CID; Cannabinoid CB(2) receptor; Cerebral glucose uptake; Cyclooxygenase-2 (COX-2); DuP697 (PubChem CID; GP1a (PubChem CID; JWH133 (PubChem CID; JZL184 (PubChem CID; LY2183240 (PubChem CID; Ouabain (PubChem CID; Positron emission tomography (PET); WIN55212-2 (PubChem CID; WWL70 (PubChem CID:17759121); ß-amyloid

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Receptor CB2 de Canabinoide / Doença de Alzheimer / Glucose Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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