The Protective Effects of Caffeic Acid Phenethyl Ester on Acetylsalicylic Acid-induced Lung Injury in Rats.
J Invest Surg
; 29(6): 328-334, 2016 Dec.
Article
em En
| MEDLINE
| ID: mdl-26980558
ABSTRACT
AIM:
We aimed to investigate the protective effect of caffeic acid phenethyl ester (CAPE) on acetylsalicylic acid (ASA)-induced lung damage in rats in the present study.METHODS:
A total of 40 rats were randomly divided into five groups, with eight rats in each group-group 1 control, not receiving any medication; group 2 ASA (50 mg/kg/day); group 3 ASA (50 mg/kg/day) plus CAPE (20 µg/kg/day); group 4 ASA (100 mg/kg/day); and group 5 ASA (100 mg/kg/day) plus CAPE (20 µg/kg/day). ASA and CAPE were given via orogastric gavage for 5 days. The total oxidant status (TOS), total antioxidant capacity (TAC), oxidant stress index (OSI), and paraoxonase-1 (PON-1) activity of the blood samples and lung tissues were determined. Histopathological examinations of the lung tissues were performed by using light microscopic methods.RESULTS:
CAPE treatment significantly increased antioxidant PON-1 level both in the lung tissue and plasma (p < .05). Plasma antioxidant marker (TAC, PON-1) levels significantly increased and oxidant marker (TOS, OSI) levels significantly decreased in CAPE-treated rats (groups 3,5) compared to ASA given no-CAPE groups (group 2,4) (p < .05). Treatment with CAPE improved pulmonary interstitial inflammation and eosinophil accumulation due to ASA histopathologically.CONCLUSION:
Eosinophil-rich inflammation and oxidative stress play important roles in ASA-induced lung toxicity, and CAPE may protect against ASA-induced lung toxicity by reduction of oxidative damage and inflammation in rats.Palavras-chave
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Álcool Feniletílico
/
Ácidos Cafeicos
/
Lesão Pulmonar
Limite:
Animals
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article