Development of a Potent, Specific CDK8 Kinase Inhibitor Which Phenocopies CDK8/19 Knockout Cells.

Koehler, Michael F T; Bergeron, Philippe; Blackwood, Elizabeth M; Bowman, Krista; Clark, Kevin R; Firestein, Ron; Kiefer, James R; Maskos, Klaus; McCleland, Mark L; Orren, Linda; Salphati, Laurent; Schmidt, Steve; Schneider, Elisabeth V; Wu, Jiansheng; Beresini, Maureen H

Koehler, Michael F T; Bergeron, Philippe; Blackwood, Elizabeth M; Bowman, Krista; Clark, Kevin R; Firestein, Ron; Kiefer, James R; Maskos, Klaus; McCleland, Mark L; Orren, Linda; Salphati, Laurent; Schmidt, Steve; Schneider, Elisabeth V; Wu, Jiansheng; Beresini, Maureen H.

Afiliação

Koehler MF; Departments of Discovery Chemistry, Translational Oncology, Structural Biology, Biochemical and Cellular Pharmacology, Pathology, Drug Metabolism and Pharmacokinetics, and Structural Biology, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Bergeron P; Departments of Discovery Chemistry, Translational Oncology, Structural Biology, Biochemical and Cellular Pharmacology, Pathology, Drug Metabolism and Pharmacokinetics, and Structural Biology, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Blackwood EM; Departments of Discovery Chemistry, Translational Oncology, Structural Biology, Biochemical and Cellular Pharmacology, Pathology, Drug Metabolism and Pharmacokinetics, and Structural Biology, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Bowman K; Departments of Discovery Chemistry, Translational Oncology, Structural Biology, Biochemical and Cellular Pharmacology, Pathology, Drug Metabolism and Pharmacokinetics, and Structural Biology, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Clark KR; Departments of Discovery Chemistry, Translational Oncology, Structural Biology, Biochemical and Cellular Pharmacology, Pathology, Drug Metabolism and Pharmacokinetics, and Structural Biology, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Firestein R; Departments of Discovery Chemistry, Translational Oncology, Structural Biology, Biochemical and Cellular Pharmacology, Pathology, Drug Metabolism and Pharmacokinetics, and Structural Biology, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Kiefer JR; Departments of Discovery Chemistry, Translational Oncology, Structural Biology, Biochemical and Cellular Pharmacology, Pathology, Drug Metabolism and Pharmacokinetics, and Structural Biology, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Maskos K; Proteros Biostructures GmbH , Bunsenstr. 7a, D-82152 Martinsried, Germany.
McCleland ML; Departments of Discovery Chemistry, Translational Oncology, Structural Biology, Biochemical and Cellular Pharmacology, Pathology, Drug Metabolism and Pharmacokinetics, and Structural Biology, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Orren L; Departments of Discovery Chemistry, Translational Oncology, Structural Biology, Biochemical and Cellular Pharmacology, Pathology, Drug Metabolism and Pharmacokinetics, and Structural Biology, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Salphati L; Departments of Discovery Chemistry, Translational Oncology, Structural Biology, Biochemical and Cellular Pharmacology, Pathology, Drug Metabolism and Pharmacokinetics, and Structural Biology, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Schmidt S; Departments of Discovery Chemistry, Translational Oncology, Structural Biology, Biochemical and Cellular Pharmacology, Pathology, Drug Metabolism and Pharmacokinetics, and Structural Biology, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Schneider EV; Proteros Biostructures GmbH, Bunsenstr. 7a, D-82152 Martinsried, Germany; Max-Planck-Institut für Biochemie, Am Klopferspitz 18a, D-82152 Martinsried, Germany.
Wu J; Departments of Discovery Chemistry, Translational Oncology, Structural Biology, Biochemical and Cellular Pharmacology, Pathology, Drug Metabolism and Pharmacokinetics, and Structural Biology, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Beresini MH; Departments of Discovery Chemistry, Translational Oncology, Structural Biology, Biochemical and Cellular Pharmacology, Pathology, Drug Metabolism and Pharmacokinetics, and Structural Biology, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.