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Obesity and Insulin Resistance Are the Main Determinants of Postprandial Lipoprotein Dysmetabolism in Polycystic Ovary Syndrome.
Kyaw Tun, Tommy; McGowan, Anne; Phelan, Niamh; Correia, Neuman; Boran, Gerard; O'Connor, Anna-Louise; Roche, Helen M; Gibney, James.
Afiliação
  • Kyaw Tun T; Department of Endocrinology and Diabetes, Tallaght Hospital, Tallaght, Dublin 24, Ireland.
  • McGowan A; Department of Endocrinology and Diabetes, Tallaght Hospital, Tallaght, Dublin 24, Ireland.
  • Phelan N; Department of Endocrinology and Diabetes, Tallaght Hospital, Tallaght, Dublin 24, Ireland.
  • Correia N; Department of Endocrinology and Diabetes, Tallaght Hospital, Tallaght, Dublin 24, Ireland.
  • Boran G; Department of Chemical Pathology, Tallaght Hospital, Tallaght, Dublin 24, Ireland.
  • O'Connor AL; Nutrigenomics Research Group, UCD Conway Institute of Biomolecular and Biomedical Research, School of Public Health and Population Science, University College Dublin, Belfield, Dublin 4, Ireland.
  • Roche HM; Nutrigenomics Research Group, UCD Conway Institute of Biomolecular and Biomedical Research, School of Public Health and Population Science, University College Dublin, Belfield, Dublin 4, Ireland.
  • Gibney J; Department of Endocrinology and Diabetes, Tallaght Hospital, Tallaght, Dublin 24, Ireland.
Int J Endocrinol ; 2016: 9545239, 2016.
Article em En | MEDLINE | ID: mdl-26989412
Postprandial dyslipidaemia may be a plausible mechanism by which polycystic ovary syndrome (PCOS) increases cardiovascular risk. We sought to investigate whether the postprandial glucose and insulin and lipid and lipoprotein responses, including that of apolipoprotein B-48 (apoB-48) containing chylomicrons, to a mixed meal are different in obese PCOS women when compared to obese control subjects and whether differences, if any, are related to obesity, insulin resistance (IR), hyperandrogenaemia, or PCOS status. 26 women with PCOS (age 30.4 ± 1.2 years (mean ± SEM), body mass index (BMI) 36.8 ± 1.5 kg/m(2)) and 26 non-PCOS subjects (age 34.1 ± 0.9 years, BMI 31.5 ± 1.0 kg/m(2)) were studied before and up to 8 hours following a standard mixed meal. AUC-triglyceride (AUC-TG) was higher and AUC-high-density lipoprotein (AUC-HDL) lower in PCOS women. These differences were not apparent when BMI was accounted for. Insulin sensitivity (S I), AUC-apoB-48, and AUC-apolipoprotein B (AUC-apoB) were found to be independent predictors of AUC-TG, accounting for 55% of the variance. Only AUC-insulin remained significantly elevated following adjustment for BMI. Obesity related IR explains postprandial hypertriglyceridaemia and hyperinsulinaemic responses. Management of obesity in premenopausal women with PCOS is likely to reduce their cardiovascular risk burden.

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2016 Tipo de documento: Article