Factors predicting poor outcomes in T1N0 oral squamous cell carcinoma: indicators for treatment intensification.
ANZ J Surg
; 86(5): 366-71, 2016 May.
Article
em En
| MEDLINE
| ID: mdl-26991038
ABSTRACT
BACKGROUND:
This study investigated the impact of adverse pathological features (APFs) amongst patients with T1N0 oral squamous cell carcinoma (OSCC) on both tumour control and survival. We aimed to investigate clinicopathological factors that would predict poor outcomes and determine a clinically relevant threshold for the recommendation of additional treatment.METHODS:
Retrospective analysis of 121 patients from a single institution (1988-2013) who were treated with surgery only (wide local excision of the primary tumour with or without neck dissection). Only patients who are pT1cN0 or pT1pN0 were included. Patients who had received adjuvant radiotherapy were excluded from the study.RESULTS:
APFs were associated with increased regional failure included tumour thickness (TT) ≥5 mm (P = 0.007), perineural invasion (PNI) (P = 0.003), infiltrative border (P = 0.030) and poor differentiation (P = 0.005). Poorly differentiated tumours were also associated with increased local failure (P = 0.03). Local control (LC), regional control (RC) and disease-specific survival (DSS) decreased with an increasing number of APFs (P = 0.009, P = <0.001 and P = 0.009, respectively). Patients with four or more APFs had significantly worse outcomes in LC (P < 0.001), RC (P < 0.001) and DSS (P < 0.001).CONCLUSION:
T1N0 OSCC exhibiting four or more APFs or demonstrating poor differentiation on histology had an increased risk of locoregional failure. The presence of PNI, infiltrative border and TT ≥5 mm are associated with increased regional failure. These factors may prompt escalation of treatment for patients with T1N0 OSCC.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Bucais
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Carcinoma de Células Escamosas
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Procedimentos Cirúrgicos Bucais
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Previsões
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Recidiva Local de Neoplasia
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Estadiamento de Neoplasias
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Guideline
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Female
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Humans
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Male
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Middle aged
País como assunto:
Oceania
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article