The Conformational Variability of FimH: Which Conformation Represents the Therapeutic Target?

Eris, Deniz; Preston, Roland C; Scharenberg, Meike; Hulliger, Fabian; Abgottspon, Daniela; Pang, Lijuan; Jiang, Xiaohua; Schwardt, Oliver; Ernst, Beat

Eris, Deniz; Preston, Roland C; Scharenberg, Meike; Hulliger, Fabian; Abgottspon, Daniela; Pang, Lijuan; Jiang, Xiaohua; Schwardt, Oliver; Ernst, Beat.

Afiliação

Eris D; Department of Pharmaceutical Sciences, Institute of Molecular Pharmacy, Pharmacenter, Klingelbergstrasse 50, 4056, Basel, Switzerland.
Preston RC; Department of Pharmaceutical Sciences, Institute of Molecular Pharmacy, Pharmacenter, Klingelbergstrasse 50, 4056, Basel, Switzerland.
Scharenberg M; Department of Pharmaceutical Sciences, Institute of Molecular Pharmacy, Pharmacenter, Klingelbergstrasse 50, 4056, Basel, Switzerland.
Hulliger F; Department of Pharmaceutical Sciences, Institute of Molecular Pharmacy, Pharmacenter, Klingelbergstrasse 50, 4056, Basel, Switzerland.
Abgottspon D; Department of Pharmaceutical Sciences, Institute of Molecular Pharmacy, Pharmacenter, Klingelbergstrasse 50, 4056, Basel, Switzerland.
Pang L; Department of Pharmaceutical Sciences, Institute of Molecular Pharmacy, Pharmacenter, Klingelbergstrasse 50, 4056, Basel, Switzerland.
Jiang X; Department of Pharmaceutical Sciences, Institute of Molecular Pharmacy, Pharmacenter, Klingelbergstrasse 50, 4056, Basel, Switzerland.
Schwardt O; Department of Pharmaceutical Sciences, Institute of Molecular Pharmacy, Pharmacenter, Klingelbergstrasse 50, 4056, Basel, Switzerland.
Ernst B; Department of Pharmaceutical Sciences, Institute of Molecular Pharmacy, Pharmacenter, Klingelbergstrasse 50, 4056, Basel, Switzerland. beat.ernst@unibas.ch.

Chembiochem ; 17(11): 1012-20, 2016 06 02.

Article em En | MEDLINE | ID: mdl-26991759

Assuntos

Adesinas de Escherichia coli/metabolismo; Proteínas de Fímbrias/metabolismo; Adesinas de Escherichia coli/genética; Escherichia coli/isolamento & purificação; Escherichia coli/metabolismo; Proteínas de Fímbrias/antagonistas & inibidores; Proteínas de Fímbrias/genética; Humanos; Manose/química; Manose/metabolismo; Mutação; Fenótipo; Ligação Proteica; Estrutura Terciária de Proteína; Infecções Urinárias/microbiologia; Infecções Urinárias/patologia; Uroplaquina Ia/química; Uroplaquina Ia/metabolismo

Palavras-chave

FimH; catch-bonds; cell adhesion; conformational variability; inhibitors

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Adesinas de Escherichia coli / Proteínas de Fímbrias Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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