Detectors for evaluating the cellular landscape of sphingomyelin- and cholesterol-rich membrane domains.
Biochim Biophys Acta
; 1861(8 Pt B): 812-829, 2016 Aug.
Article
em En
| MEDLINE
| ID: mdl-26993577
ABSTRACT
Although sphingomyelin and cholesterol are major lipids of mammalian cells, the detailed distribution of these lipids in cellular membranes remains still obscure. However, the recent development of protein probes that specifically bind sphingomyelin and/or cholesterol provides new information about the landscape of the lipid domains that are enriched with sphingomyelin or cholesterol or both. Here, we critically summarize the tools to study distribution and dynamics of sphingomyelin and cholesterol. This article is part of a Special Issue entitled The cellular lipid landscape edited by Tim P. Levine and Anant K. Menon.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Esfingomielinas
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Colesterol
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Técnicas de Sonda Molecular
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Microdomínios da Membrana
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Lipídeos de Membrana
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article