[Switching and combining strategies of antidepressant medications]. / Dépression résistante : les stratégies de changement et d'association de médicaments antidépresseurs.
Presse Med
; 45(3): 329-37, 2016 Mar.
Article
em Fr
| MEDLINE
| ID: mdl-26995511
ABSTRACT
Switching antidepressant medication may be helpful in depressed patients having no benefit from the initial antidepressant treatment. Before considering switching strategy, the initial antidepressant treatment should produce no therapeutic effect after at least 4 weeks of administration at adequate dosage. Choosing an antidepressant of pharmacologically distinct profile fails to consistently demonstrate a significant superiority in terms of effectiveness over the switching to another antidepressant within the same pharmacological class. Augmenting SSRI/SNRIs with mirtazapine/mianserin has become the most recommended strategy of antidepressant combinations. Augmenting SSRI with tricyclic drugs is now a less recommended strategy of antidepressant combinations given the increased risk for the occurrence of pharmacokinetic drug-drug interactions and adverse effects.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transtorno Depressivo
/
Antidepressivos
Tipo de estudo:
Guideline
/
Risk_factors_studies
Limite:
Humans
Idioma:
Fr
Ano de publicação:
2016
Tipo de documento:
Article