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Functional identification of a neurocircuit regulating blood glucose.
Meek, Thomas H; Nelson, Jarrell T; Matsen, Miles E; Dorfman, Mauricio D; Guyenet, Stephan J; Damian, Vincent; Allison, Margaret B; Scarlett, Jarrad M; Nguyen, Hong T; Thaler, Joshua P; Olson, David P; Myers, Martin G; Schwartz, Michael W; Morton, Gregory J.
Afiliação
  • Meek TH; Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, WA 98195;
  • Nelson JT; Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, WA 98195;
  • Matsen ME; Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, WA 98195;
  • Dorfman MD; Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, WA 98195;
  • Guyenet SJ; Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, WA 98195;
  • Damian V; Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, WA 98195;
  • Allison MB; Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI 48105;
  • Scarlett JM; Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, WA 98195;
  • Nguyen HT; Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, WA 98195;
  • Thaler JP; Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, WA 98195;
  • Olson DP; Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI 48105;
  • Myers MG; Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48105.
  • Schwartz MW; Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, WA 98195;
  • Morton GJ; Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, WA 98195; gjmorton@u.washington.edu.
Proc Natl Acad Sci U S A ; 113(14): E2073-82, 2016 Apr 05.
Article em En | MEDLINE | ID: mdl-27001850
ABSTRACT
Previous studies implicate the hypothalamic ventromedial nucleus (VMN) in glycemic control. Here, we report that selective inhibition of the subset of VMN neurons that express the transcription factor steroidogenic-factor 1 (VMN(SF1) neurons) blocks recovery from insulin-induced hypoglycemia whereas, conversely, activation of VMN(SF1) neurons causes diabetes-range hyperglycemia. Moreover, this hyperglycemic response is reproduced by selective activation of VMN(SF1) fibers projecting to the anterior bed nucleus of the stria terminalis (aBNST), but not to other brain areas innervated by VMN(SF1) neurons. We also report that neurons in the lateral parabrachial nucleus (LPBN), a brain area that is also implicated in the response to hypoglycemia, make synaptic connections with the specific subset of glucoregulatory VMN(SF1) neurons that project to the aBNST. These results collectively establish a physiological role in glucose homeostasis for VMN(SF1) neurons and suggest that these neurons are part of an ascending glucoregulatory LPBN→VMN(SF1)→aBNST neurocircuit.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Núcleo Hipotalâmico Ventromedial / Glicemia / Neurônios Aferentes Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Núcleo Hipotalâmico Ventromedial / Glicemia / Neurônios Aferentes Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article