Fast analysis of caffeine in beverages and drugs by paper spray tandem mass spectrometry.
Anal Bioanal Chem
; 408(14): 3783-7, 2016 05.
Article
em En
| MEDLINE
| ID: mdl-27002611
ABSTRACT
A simple and fast method based on paper spray mass spectrometry for the determination of caffeine in commercial beverages and drugs has been developed; the analyses were carried out in MRM mode, monitoring the transitions m/z 195 â m/z 138 for caffeine and m/z 198 â m/z 140 for the labeled internal standard. To verify the reliability of the proposed approach, a spiked sample (soda drink and paracetamol tablet) with a known amount of caffeine has been prepared and analyzed by PS-MS, providing accuracy values about 100 %; the LOQ and LOD values were calculated at 1.2 and 1.6 µg/mL, respectively. Both beverages and drugs were also analyzed with the classic analytical method based on LC-UV measurements, showing consistent results between the two approaches, thus confirming the reliability of the developed ambient MS determination. Graphical Abstract The assay of caffeine by paper mass spectrometry.
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Base de dados:
MEDLINE
Assunto principal:
Bebidas
/
Cafeína
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Preparações Farmacêuticas
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Espectrometria de Massas em Tandem
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article