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Role of oral pentosan polysulphate in the reduction of local side effects of BCG therapy in patients with non-muscle-invasive bladder cancer: a pilot study.
Yadav, Suresh; Tomar, Vinay; Yadav, Sher Singh; Priyadarshi, Shivam; Banerjee, Indraneel.
Afiliação
  • Yadav S; Department of Urology and Renal Transplantation, S.M.S. Medical College and Hospital, Jaipur, India. drsureshyadav7@gmail.com.
  • Tomar V; Department of Urology and Renal Transplantation, S.M.S. Medical College and Hospital, Jaipur, India.
  • Yadav SS; Department of Urology and Renal Transplantation, S.M.S. Medical College and Hospital, Jaipur, India.
  • Priyadarshi S; Department of Urology and Renal Transplantation, S.M.S. Medical College and Hospital, Jaipur, India.
  • Banerjee I; Department of Urology and Renal Transplantation, S.M.S. Medical College and Hospital, Jaipur, India.
BJU Int ; 118(5): 758-762, 2016 Nov.
Article em En | MEDLINE | ID: mdl-27010115
OBJECTIVE: To assess the role of oral pentosan polysulphate (PPS) in the reduction of bacille Calmette-Guérin (BCG)-related local side effects in patients with high grade Ta/T1 non-muscle-invasive bladder cancer (NMIBC). PATIENTS AND METHODS: A total of 32 symptomatic patients receiving BCG instillation were randomized into three groups: group A received placebo (vitamin B complex tablet) thrice daily; group B received PPS 100 mg thrice daily; and group C received PPS 100 mg once daily and placebo (vitamin B complex tablet) twice daily for 6 weeks. A visual analogue scale (VAS) score for bladder pain, Overactive Bladder-Validated 8 Question Screener (OAB-V8) scores and dysuria were evaluated in the three groups before and during each weekly visit for BCG instillation. RESULTS: The mean ± sd post-treatment VAS scores were significantly lower in groups B (4.4 ± 1.2) and C (5.8 ± 0.8) than in group A (8 ± 0.4). In addition, the post-treatment VAS score was significantly lower in group B than in group C (P<0.01). The mean post-treatment OAB-V8 score was significantly lower only in group B (decreased from 15.5 to 9.7). Dysuria decreased in groups B and C but persisted in group A. CONCLUSION: The present study shows that oral PPS (100 mg) thrice daily is effective in relieving BCG-related local side effects.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Poliéster Sulfúrico de Pentosana / Neoplasias da Bexiga Urinária / Vacina BCG / Adjuvantes Imunológicos Tipo de estudo: Clinical_trials / Observational_studies Limite: Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Poliéster Sulfúrico de Pentosana / Neoplasias da Bexiga Urinária / Vacina BCG / Adjuvantes Imunológicos Tipo de estudo: Clinical_trials / Observational_studies Limite: Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article