Cutting Edge: Integrin α4 Is Required for Regulatory B Cell Control of Experimental Autoimmune Encephalomyelitis.
J Immunol
; 196(9): 3542-6, 2016 05 01.
Article
em En
| MEDLINE
| ID: mdl-27016608
ABSTRACT
The neutralization of integrin α4 (Itga4) is currently used as treatment in multiple sclerosis. Although most studies have focused on its function on lymphocyte migration to the CNS, we have uncovered the importance of Itga4 for the generation of regulatory B cells in peripheral immune organs and their control of pathogenic T cell response and CNS pathology. Our study underscores the importance of looking at the dual role of B cells in CNS autoimmunity and provides important perspectives regarding the efficacy and side effects associated with Itga4 neutralization and other B cell-targeting therapies.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sistema Nervoso Central
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Integrina alfa4
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Encefalomielite Autoimune Experimental
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Linfócitos B Reguladores
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article