Functional effects of cannabinoids during dopaminergic specification of human neural precursors derived from induced pluripotent stem cells.

Stanslowsky, Nancy; Jahn, Kirsten; Venneri, Anna; Naujock, Maximilian; Haase, Alexandra; Martin, Ulrich; Frieling, Helge; Wegner, Florian

Stanslowsky, Nancy; Jahn, Kirsten; Venneri, Anna; Naujock, Maximilian; Haase, Alexandra; Martin, Ulrich; Frieling, Helge; Wegner, Florian.

Afiliação

Stanslowsky N; Department of Neurology, Hannover Medical School, Hannover, Germany.
Jahn K; Center for Addiction Research, Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany.
Venneri A; Department of Neurology, Hannover Medical School, Hannover, Germany.
Naujock M; Department of Neurology, Hannover Medical School, Hannover, Germany.
Haase A; Center for Systems Neuroscience, Hannover, Germany.
Martin U; Leibniz Research Laboratories for Biotechnology and Artificial Organs, Department of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany.
Frieling H; Leibniz Research Laboratories for Biotechnology and Artificial Organs, Department of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany.
Wegner F; REBIRTH-Cluster of Excellence, Hannover, Germany.

Addict Biol ; 22(5): 1329-1342, 2017 Sep.

Article em En | MEDLINE | ID: mdl-27027565

Assuntos

Ácidos Araquidônicos/farmacologia; Agonistas de Receptores de Canabinoides/farmacologia; Neurônios Dopaminérgicos/efeitos dos fármacos; Dronabinol/farmacologia; Endocanabinoides/farmacologia; Células-Tronco Pluripotentes Induzidas/efeitos dos fármacos; Células-Tronco Neurais/efeitos dos fármacos; Neurogênese/efeitos dos fármacos; Alcamidas Poli-Insaturadas/farmacologia; Metilação de DNA/efeitos dos fármacos; Relação Dose-Resposta a Droga; Sangue Fetal/citologia; Humanos; Técnicas In Vitro

Palavras-chave

cannabinoids; dopaminergic differentiation; epigenetic; human induced pluripotent stem cells (hiPSCs); neurogenesis; patch clamp

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dronabinol / Ácidos Araquidônicos / Endocanabinoides / Alcamidas Poli-Insaturadas / Neurogênese / Células-Tronco Pluripotentes Induzidas / Células-Tronco Neurais / Neurônios Dopaminérgicos / Agonistas de Receptores de Canabinoides Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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