[GH10 Family of Glycoside Hydrolases: Structure and Evolutionary Connections].
Mol Biol (Mosk)
; 50(1): 151-60, 2016.
Article
em Ru
| MEDLINE
| ID: mdl-27028821
ABSTRACT
Evolutionary connections were analyzed for endo-ß-xylanases, which possess the GH10 family catalytic domains. A homology search yielded thrice as many proteins as are available from the Carbohydrate-Active Enzymes (CAZy) database. Lateral gene transfer was shown to play an important role in evolution of bacterial proteins of the family, especially in the phyla Acidobacteria, Cyanobacteria, Planctomycetes, Spirochaetes, and Verrucomicrobia. In the case of Verrucomicrobia, 23 lateral transfers from organisms of other phyla were detected. Evolutionary relationships were observed between the GH10 family domains and domains with the TIM-barrel tertiary structure from several other glycosidase families. The GH39 family of glycoside hydrolases showed the closest relationship. Unclassified homologs were grouped into 12 novel families of putative glycoside hydrolases (GHL51-GHL62).
Palavras-chave
GH-A clan; GH10 family; GHL families; PF00331 family; PSI Protein Classifier; PSI-BLAST; Verrucomicrobia; carbohydrate metabolism; endoglycosidase; gene annotation; glycoside hydrolase; lateral transfer; new protein families; protein evolution; protein superfamily; search for homologs; xylan utilization; ß-xylanase
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Bactérias
/
Evolução Molecular
/
Transferência Genética Horizontal
/
Glicosídeo Hidrolases
Idioma:
Ru
Ano de publicação:
2016
Tipo de documento:
Article