Yeast-containing feed additive alters gene expression profiles associated with innate immunity in whole blood of a rodent model.
Innate Immun
; 22(4): 249-56, 2016 05.
Article
em En
| MEDLINE
| ID: mdl-27033362
ABSTRACT
Feeding a yeast-containing additive (YCA; OmniGen-AF) improves immune responses in ruminant livestock and reduces subsequent production losses. The objective was to identify molecular pathways by which dietary YCA may modify immune responses using a rodent model. Thirty-seven healthy, unchallenged CD rats received a diet containing 0 (control; n = 5, only 28 d), 0.5% (n = 15) or 1% (n = 17) YCA for 7 (n = 4/group), 14 (n = 3 or 4/group), 21 (n = 3 or 4/group) or 28 (n = 5/group) d. At the end of the feeding periods, whole blood was collected and the isolated RNA was analyzed for the expression of 84 genes involved in innate and cell-mediated adaptive immune responses. Three bacterial pattern recognition receptors TLR1 (0.5% + 2.01; 1% + 2.38), TLR6 (0.5% + 2.11; 1% + 2.34) and NOD2 (0.5% + 2.32; 1% + 2.23), two APC surface receptors CD1D1 (0.5% + 1.75; 1% + 2.33) and CD80 (0.5% +2.45; 1% +3.00), and the cell signaling molecule MAPK8 (0.5% +1.87; 1% +2.35) were significantly up-regulated by YCA at both inclusion rates. In conclusion, feeding YCA may potentially increase recognition and responses to bacterial pathogens and T-cell activation and differentiation and thereby maintain health and prevent production losses.
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Base de dados:
MEDLINE
Assunto principal:
Leveduras
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Células Sanguíneas
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Transcriptoma
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Aditivos Alimentares
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Ração Animal
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article