Diabetic Microangiopathy Is an Independent Predictor of Incident Diabetic Foot Ulcer.
J Diabetes Res
; 2016: 5938540, 2016.
Article
em En
| MEDLINE
| ID: mdl-27034962
ABSTRACT
AIM:
To determine the diabetic foot ulcer incidence and examine its association with microangiopathy complications, including diabetic retinopathy (DR) and albuminuria (Alb), in type 2 diabetes patients.METHODS:
This was a retrospective cohort study of 1,305 patients with type 2 diabetes who were assigned to the following groups Category 1, normoalbuminuria without DR (n = 712); Category 2, Alb without DR (n = 195); Category 3, normoalbuminuria with DR (n = 185); and Category 4, Alb with DR (n = 213). Cox proportional hazard models were used to compare the risks of developing diabetic foot ulcers across the categories.RESULTS:
During 14,249 person-years of follow-up, 50 subjects developed diabetic foot ulcers, with incidence rates of 1.6/1,000, 1.5/1,000, 3.4/1,000, and 12.5/1,000 person-years in Categories 1, 2, 3, and 4, respectively. After adjusting for the presence of diabetic neuropathy and macroangiopathy, the hazard ratios and 95% confidence intervals (CIs) for the risk of diabetic foot ulcer development were 0.66 (95% CI, 0.18-2.36), 1.72 (95% CI, 0.67-4.42), and 3.17 (95% CI, 1.52-6.61) in Categories 2, 3, and 4, respectively, compared with Category 1.CONCLUSION:
The presence of DR and Alb significantly increases the risk of diabetic foot ulcer development.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Pé Diabético
/
Diabetes Mellitus Tipo 2
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Retinopatia Diabética
/
Albuminúria
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
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Male
/
Middle aged
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article