The platelet isoform of phosphofructokinase contributes to metabolic reprogramming and maintains cell proliferation in clear cell renal cell carcinoma.

Wang, Jun; Zhang, Ping; Zhong, Jie; Tan, Mingyue; Ge, Jifu; Tao, Le; Li, Yakui; Zhu, Yemin; Wu, Lifang; Qiu, Jianxin; Tong, Xuemei

Wang, Jun; Zhang, Ping; Zhong, Jie; Tan, Mingyue; Ge, Jifu; Tao, Le; Li, Yakui; Zhu, Yemin; Wu, Lifang; Qiu, Jianxin; Tong, Xuemei.

Afiliação

Wang J; Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhang P; Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhong J; Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Tan M; Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ge J; Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Tao L; Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Li Y; Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhu Y; Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wu L; Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Qiu J; Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Tong X; Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Oncotarget ; 7(19): 27142-57, 2016 May 10.

Article em En | MEDLINE | ID: mdl-27049827

Assuntos

Carcinoma de Células Renais/genética; Proliferação de Células/genética; Neoplasias Renais/genética; Fosfofrutoquinases/genética; Idoso; Animais; Apoptose/genética; Plaquetas/enzimologia; Carcinoma de Células Renais/metabolismo; Carcinoma de Células Renais/patologia; Pontos de Checagem do Ciclo Celular/genética; Linhagem Celular Tumoral; Feminino; Regulação Neoplásica da Expressão Gênica; Glicólise/genética; Humanos; Isoenzimas/genética; Isoenzimas/metabolismo; Neoplasias Renais/metabolismo; Neoplasias Renais/patologia; Masculino; Camundongos Nus; Pessoa de Meia-Idade; Via de Pentose Fosfato/genética; Fosfofrutoquinases/metabolismo; Interferência de RNA; Transplante Heterólogo; Adulto Jovem

Palavras-chave

PFKP; aerobic glycolysis; clear cell renal cell carcinoma; proliferation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma de Células Renais / Fosfofrutoquinases / Proliferação de Células / Neoplasias Renais Limite: Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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