Inflammatory Cell Upregulation of the Lid Wiper in Contact Lens Dry Eye.
Optom Vis Sci
; 93(8): 917-24, 2016 08.
Article
em En
| MEDLINE
| ID: mdl-27055062
ABSTRACT
PURPOSE:
To determine if Langerhans cells in the lid wiper are upregulated in contact lens-induced dry eye (CLIDE).METHODS:
The lid wiper of one eye of 17 participants with CLIDE (assessed using the CLDEQ-8) and 29 without CLIDE (NO-CLIDE) was examined using a Heidelberg laser scanning confocal microscope after 6 months wear of daily disposable hydrogel contact lenses (Biomedics 1 day Extra). Twenty non-contact-lens-wearing controls were also examined. Langerhans cell density (LCD) in each participant was taken as the mean cell count calculated manually from six clear, randomly selected images of known dimensions.RESULTS:
There were significant overall differences in LCD in the lid wiper among the three groups (p < 0.001). LCD was significantly greater in the lid wiper in CLIDE (17 ± 10 cells/mm) compared to controls (8 ± 4 cells/mm) (p < 0.001); however, there was no difference in LCD between NO-CLIDE (10 ± 5 cells/mm) and controls (p = 0.489). LCD was significantly greater in CLIDE than NO-CLIDE (p = 0.002).CONCLUSIONS:
Langerhans cells in the lid wiper are upregulated in CLIDE, suggesting an inflammatory component in the etiology of this condition.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Síndromes do Olho Seco
/
Células de Langerhans
/
Lentes de Contato
/
Pálpebras
Tipo de estudo:
Etiology_studies
Limite:
Adolescent
/
Adult
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Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article