Your browser doesn't support javascript.
loading
Autoantibodies specific to estrogen receptor alpha act as estrogen agonists and their levels correlate with breast cancer cell proliferation.
Maselli, Angela; Capoccia, Sara; Pugliese, Patrizia; Raggi, Carla; Cirulli, Francesca; Fabi, Alessandra; Malorni, Walter; Pierdominici, Marina; Ortona, Elena.
Afiliação
  • Maselli A; Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità , Rome, Italy.
  • Capoccia S; Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità , Rome, Italy.
  • Pugliese P; Department of Medical Oncology, Regina Elena National Cancer Institute , Rome, Italy.
  • Raggi C; Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità , Rome, Italy.
  • Cirulli F; Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità , Rome, Italy.
  • Fabi A; Department of Medical Oncology, Regina Elena National Cancer Institute , Rome, Italy.
  • Malorni W; Department of Therapeutic Research and Medicine Evaluation, Istituto Superiore di Sanità, Rome, Italy; San Raffaele Pisana Institute, Rome, Italy.
  • Pierdominici M; Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità , Rome, Italy.
  • Ortona E; Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy; San Raffaele Pisana Institute, Rome, Italy.
Oncoimmunology ; 5(2): e1074375, 2016 Feb.
Article em En | MEDLINE | ID: mdl-27057440
Estrogen receptors have recently been demonstrated at the cell surface. Unlike nuclear receptors, they are able to trigger rapid responses inside the cells. In this study, we evaluated the presence and the possible role of autoantibodies specific to estrogen receptor (anti-ER Abs) in the peripheral blood of breast cancer patients. Anti-ERα Abs were detectable in 22/48 (46%) patients' sera and their levels positively correlated with the percentage of Ki-67-positive breast cancer cells. Anti-ERα Abs purified from breast cancer patients' sera were able: (i) to recognize ERα epitopes expressed at the cell surface of ER-positive breast cancer cells, (ii) to trigger rapid extracellular signal-regulated kinase (ERK) phosphorylation, and (iii) to induce cell proliferation. Our results suggest that anti-ERα Abs can act as estrogen agonists playing a pathogenetic role as breast cancer-promoting factors. These autoantibodies could also be considered as possible peripheral blood biomarkers indicative of the breast cancer growth potential.
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2016 Tipo de documento: Article