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Initial Assessment of the Molecular Epidemiology of blaNDM-1 in Colombia.
Rojas, Laura J; Wright, Meredith S; De La Cadena, Elsa; Motoa, Gabriel; Hujer, Kristine M; Villegas, Maria V; Adams, Mark D; Bonomo, Robert A.
Afiliação
  • Rojas LJ; Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
  • Wright MS; J. Craig Venter Institute, La Jolla, California, USA.
  • De La Cadena E; International Center for Medical Research and Training, CIDEIM, Cali, Colombia.
  • Motoa G; International Center for Medical Research and Training, CIDEIM, Cali, Colombia.
  • Hujer KM; Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
  • Villegas MV; International Center for Medical Research and Training, CIDEIM, Cali, Colombia.
  • Adams MD; J. Craig Venter Institute, La Jolla, California, USA madams@jcvi.org robert.bonomo@va.gov.
  • Bonomo RA; Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio, USA Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA Research Service, Louis Stokes Cleve
Antimicrob Agents Chemother ; 60(7): 4346-50, 2016 07.
Article em En | MEDLINE | ID: mdl-27067339
ABSTRACT
We report complete genome sequences of four blaNDM-1-harboring Gram-negative multidrug-resistant (MDR) isolates from Colombia. The blaNDM-1 genes were located on 193-kb Inc FIA, 178-kb Inc A/C2, and 47-kb (unknown Inc type) plasmids. Multilocus sequence typing (MLST) revealed that these isolates belong to sequence type 10 (ST10) (Escherichia coli), ST392 (Klebsiella pneumoniae), and ST322 and ST464 (Acinetobacter baumannii and Acinetobacter nosocomialis, respectively). Our analysis identified that the Inc A/C2 plasmid in E. coli contained a novel complex transposon (Tn125 and Tn5393 with three copies of blaNDM-1) and a recombination "hot spot" for the acquisition of new resistance determinants.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Epidemiologia Molecular / Acinetobacter baumannii Tipo de estudo: Screening_studies País como assunto: America do sul / Colombia Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Epidemiologia Molecular / Acinetobacter baumannii Tipo de estudo: Screening_studies País como assunto: America do sul / Colombia Idioma: En Ano de publicação: 2016 Tipo de documento: Article