Initial Assessment of the Molecular Epidemiology of blaNDM-1 in Colombia.
Antimicrob Agents Chemother
; 60(7): 4346-50, 2016 07.
Article
em En
| MEDLINE
| ID: mdl-27067339
ABSTRACT
We report complete genome sequences of four blaNDM-1-harboring Gram-negative multidrug-resistant (MDR) isolates from Colombia. The blaNDM-1 genes were located on 193-kb Inc FIA, 178-kb Inc A/C2, and 47-kb (unknown Inc type) plasmids. Multilocus sequence typing (MLST) revealed that these isolates belong to sequence type 10 (ST10) (Escherichia coli), ST392 (Klebsiella pneumoniae), and ST322 and ST464 (Acinetobacter baumannii and Acinetobacter nosocomialis, respectively). Our analysis identified that the Inc A/C2 plasmid in E. coli contained a novel complex transposon (Tn125 and Tn5393 with three copies of blaNDM-1) and a recombination "hot spot" for the acquisition of new resistance determinants.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Epidemiologia Molecular
/
Acinetobacter baumannii
Tipo de estudo:
Screening_studies
País como assunto:
America do sul
/
Colombia
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article