Optogenetic activation reveals distinct roles of PIP3 and Akt in adipocyte insulin action.

Xu, Yingke; Nan, Di; Fan, Jiannan; Bogan, Jonathan S; Toomre, Derek

Xu, Yingke; Nan, Di; Fan, Jiannan; Bogan, Jonathan S; Toomre, Derek.

Afiliação

Xu Y; Department of Biomedical Engineering, MOE Key Laboratory of Biomedical Engineering, Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou 310027, China Department of Cell Biology, Yale University Schoo
Nan D; Department of Biomedical Engineering, MOE Key Laboratory of Biomedical Engineering, Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou 310027, China.
Fan J; Department of Biomedical Engineering, MOE Key Laboratory of Biomedical Engineering, Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou 310027, China.
Bogan JS; Department of Cell Biology, Yale University School of Medicine, New Haven, 06510, USA Section of Endocrinology and Metabolism, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520-8020, USA.
Toomre D; Department of Cell Biology, Yale University School of Medicine, New Haven, 06510, USA yingkexu@zju.edu.cn derek.toomre@yale.edu.

J Cell Sci ; 129(10): 2085-95, 2016 05 15.

Article em En | MEDLINE | ID: mdl-27076519

Assuntos

Adipócitos/metabolismo; Transportador de Glucose Tipo 4/genética; Fosfatidilinositol 3-Quinases/genética; Proteínas Proto-Oncogênicas c-akt/genética; Células 3T3; Adipócitos/efeitos dos fármacos; Animais; Membrana Celular/genética; Membrana Celular/metabolismo; Exocitose/genética; Glucose/metabolismo; Humanos; Insulina/administração & dosagem; Insulina/metabolismo; Camundongos; Optogenética; Transporte Proteico/genética; Transdução de Sinais

Palavras-chave

Exocytosis; Glucose transporter; Insulin signaling; Optogenetics; TIRFM

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Adipócitos / Fosfatidilinositol 3-Quinases / Proteínas Proto-Oncogênicas c-akt / Transportador de Glucose Tipo 4 Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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