Your browser doesn't support javascript.
loading
Tumor cell intravasation.
Chiang, Serena P H; Cabrera, Ramon M; Segall, Jeffrey E.
Afiliação
  • Chiang SP; Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York.
  • Cabrera RM; Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York.
  • Segall JE; Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York jeffrey.segall@einstein.yu.edu.
Am J Physiol Cell Physiol ; 311(1): C1-C14, 2016 07 01.
Article em En | MEDLINE | ID: mdl-27076614
The process of entering the bloodstream, intravasation, is a necessary step in the development of distant metastases. The focus of this review is on the pathways and molecules that have been identified as being important based on current in vitro and in vivo assays for intravasation. Properties of the vasculature which are important for intravasation include microvessel density and also diameter of the vasculature, with increased intravasation correlating with increased vessel diameter in some tumors. TGFB signaling can enhance intravasation at least in part through induction of EMT, and we discuss other TGFB target genes that are important for intravasation. In addition to TGFB signaling, a number of studies have demonstrated that activation of EGF receptor family members stimulates intravasation, with downstream signaling through PI3K, N-WASP, RhoA, and WASP to induce invadopodia. With respect to proteases, there is strong evidence for contributions by uPA/uPAR, while the roles of MMPs in intravasation may be more tumor specific. Other cells including macrophages, fibroblasts, neutrophils, and platelets can also play a role in enhancing tumor cell intravasation. The technology is now available to interrogate the expression patterns of circulating tumor cells, which will provide an important reality check for the model systems being used. With a better understanding of the mechanisms underlying intravasation, the goal is to provide new opportunities for improving prognosis as well as potentially developing new treatments.
Assuntos
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Movimento Celular / Microvasos / Células Neoplásicas Circulantes / Neoplasias / Neovascularização Patológica Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Movimento Celular / Microvasos / Células Neoplásicas Circulantes / Neoplasias / Neovascularização Patológica Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article