Defining and improving the genome-wide specificities of CRISPR-Cas9 nucleases.

Tsai, Shengdar Q; Joung, J Keith

Tsai, Shengdar Q; Joung, J Keith.

Afiliação

Tsai SQ; Molecular Pathology Unit, Center for Cancer Research, and Center for Computational and Integrative Biology, Massachusetts General Hospital, 149 13th Street, Charlestown, Massachusetts 02129, USA; and the Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Joung JK; Molecular Pathology Unit, Center for Cancer Research, and Center for Computational and Integrative Biology, Massachusetts General Hospital, 149 13th Street, Charlestown, Massachusetts 02129, USA; and the Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.

Nat Rev Genet ; 17(5): 300-12, 2016 May.

Article em En | MEDLINE | ID: mdl-27087594

Assuntos

Sistemas CRISPR-Cas/genética; DNA/genética; Endonucleases/metabolismo; Engenharia Genética; Genoma Humano; Humanos

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: DNA / Engenharia Genética / Genoma Humano / Endonucleases / Sistemas CRISPR-Cas Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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