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Identification of Cyproheptadine as an Inhibitor of SET Domain Containing Lysine Methyltransferase 7/9 (Set7/9) That Regulates Estrogen-Dependent Transcription.
Takemoto, Yasushi; Ito, Akihiro; Niwa, Hideaki; Okamura, Mutsumi; Fujiwara, Takashi; Hirano, Tomoya; Handa, Noriko; Umehara, Takashi; Sonoda, Takeshi; Ogawa, Kenji; Tariq, Mohammad; Nishino, Norikazu; Dan, Shingo; Kagechika, Hiroyuki; Yamori, Takao; Yokoyama, Shigeyuki; Yoshida, Minoru.
Afiliação
  • Takemoto Y; Chemical Genetics Laboratory, RIKEN , 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
  • Ito A; Chemical Genetics Laboratory, RIKEN , 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
  • Niwa H; Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science , 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
  • Okamura M; RIKEN Systems and Structural Biology Center , 1-7-22 Suehiro-cho, Tsurumi, Yokohama, Kanagawa 230-0045, Japan.
  • Fujiwara T; Division of Molecular Pharmacology, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 3-10-6 Ariake, Koto-ku, Tokyo 135-8550, Japan.
  • Hirano T; Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU) , 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan.
  • Handa N; Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU) , 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan.
  • Umehara T; RIKEN Systems and Structural Biology Center , 1-7-22 Suehiro-cho, Tsurumi, Yokohama, Kanagawa 230-0045, Japan.
  • Sonoda T; RIKEN Systems and Structural Biology Center , 1-7-22 Suehiro-cho, Tsurumi, Yokohama, Kanagawa 230-0045, Japan.
  • Ogawa K; Drug Discovery Platforms Cooperation Division, RIKEN Center for Sustainable Resource Science , 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
  • Tariq M; Chemical Genetics Laboratory, RIKEN , 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
  • Nishino N; Chemical Genetics Laboratory, RIKEN , 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
  • Dan S; Graduate School of Science and Engineering, Saitama University , 645 Shimo-Okubo, Sakura-ku, Saitama 338-8570, Japan.
  • Kagechika H; Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology , 2-4 Hibikino, Wakamatsu, Kitakyushu, Fukuoka 808-0196, Japan.
  • Yamori T; Division of Molecular Pharmacology, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 3-10-6 Ariake, Koto-ku, Tokyo 135-8550, Japan.
  • Yokoyama S; Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU) , 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan.
  • Yoshida M; Division of Molecular Pharmacology, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 3-10-6 Ariake, Koto-ku, Tokyo 135-8550, Japan.
J Med Chem ; 59(8): 3650-60, 2016 04 28.
Article em En | MEDLINE | ID: mdl-27088648
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transcrição Gênica / Histona-Lisina N-Metiltransferase / Ciproeptadina / Inibidores Enzimáticos / Estrogênios Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transcrição Gênica / Histona-Lisina N-Metiltransferase / Ciproeptadina / Inibidores Enzimáticos / Estrogênios Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article