Discovery and Optimization of Macrocyclic Quinoxaline-pyrrolo-dihydropiperidinones as Potent Pim-1/2 Kinase Inhibitors.

Cee, Victor J; Chavez, Frank; Herberich, Bradley; Lanman, Brian A; Pettus, Liping H; Reed, Anthony B; Wu, Bin; Wurz, Ryan P; Andrews, Kristin L; Chen, Jie; Hickman, Dean; Laszlo, Jimmy; Lee, Matthew R; Guerrero, Nadia; Mattson, Bethany K; Nguyen, Yen; Mohr, Christopher; Rex, Karen; Sastri, Christine E; Wang, Paul; Wu, Qiong; Wu, Tian; Xu, Yang; Zhou, Yihong; Winston, Jeffrey T; Lipford, J Russell; Tasker, Andrew S; Wang, Hui-Ling

Cee, Victor J; Chavez, Frank; Herberich, Bradley; Lanman, Brian A; Pettus, Liping H; Reed, Anthony B; Wu, Bin; Wurz, Ryan P; Andrews, Kristin L; Chen, Jie; Hickman, Dean; Laszlo, Jimmy; Lee, Matthew R; Guerrero, Nadia; Mattson, Bethany K; Nguyen, Yen; Mohr, Christopher; Rex, Karen; Sastri, Christine E; Wang, Paul; Wu, Qiong; Wu, Tian; Xu, Yang; Zhou, Yihong; Winston, Jeffrey T; Lipford, J Russell; Tasker, Andrew S; Wang, Hui-Ling.

Afiliação

Cee VJ; Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
Chavez F; Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
Herberich B; Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
Lanman BA; Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
Pettus LH; Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
Reed AB; Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
Wu B; Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
Wurz RP; Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
Andrews KL; Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
Chen J; Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
Hickman D; Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
Laszlo J; Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
Lee MR; Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
Guerrero N; Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
Mattson BK; Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
Nguyen Y; Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
Mohr C; Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
Rex K; Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
Sastri CE; Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
Wang P; Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
Wu Q; Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
Wu T; Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
Xu Y; Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
Zhou Y; Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
Winston JT; Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
Lipford JR; Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
Tasker AS; Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
Wang HL; Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.