Getting the Skinny on CD4(+) T Cell Survival in Fatty Livers.

Walker, Christopher M; Lemon, Stanley M

Walker, Christopher M; Lemon, Stanley M.

Afiliação

Walker CM; Center for Vaccines and Immunity, Nationwide Children's Hospital and Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, OH 43205, USA. Electronic address: christopher.walker@nationwidechildrens.org.
Lemon SM; Lineberger Comprehensive Cancer Center, Division of Infectious Diseases, Department of Medicine and Department of Microbiology & Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27517-7292, USA.

Immunity ; 44(4): 725-7, 2016 Apr 19.

Article em En | MEDLINE | ID: mdl-27096315

ABSTRACT

ABSTRACT

Non-alcoholic fatty liver disease is associated with hepatocellular carcinoma. In the March 10 issue of Nature, Greten and colleagues report that this metabolic disruption affects tumor surveillance by depleting CD4+ T helper cells through lipotoxic mechanisms associated with NAFLD.

Assuntos

Carcinoma Hepatocelular/imunologia; Sobrevivência Celular/imunologia; Vigilância Imunológica/imunologia; Neoplasias Hepáticas/imunologia; Hepatopatia Gordurosa não Alcoólica/imunologia; Linfócitos T Auxiliares-Indutores/imunologia; Animais; Humanos; Camundongos; Hepatopatia Gordurosa não Alcoólica/patologia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sobrevivência Celular / Linfócitos T Auxiliares-Indutores / Carcinoma Hepatocelular / Hepatopatia Gordurosa não Alcoólica / Vigilância Imunológica / Neoplasias Hepáticas Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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