Residues in the PB2 and PA genes contribute to the pathogenicity of avian H7N3 influenza A virus in DBA/2 mice.

DesRochers, Brittany L; Chen, Rita E; Gounder, Anshu P; Pinto, Amelia K; Bricker, Traci; Linton, Camille N; Rogers, Corianne D; Williams, Graham D; Webby, Richard J; Boon, Adrianus C M

DesRochers, Brittany L; Chen, Rita E; Gounder, Anshu P; Pinto, Amelia K; Bricker, Traci; Linton, Camille N; Rogers, Corianne D; Williams, Graham D; Webby, Richard J; Boon, Adrianus C M.

Afiliação

DesRochers BL; Departments of Internal Medicine, Molecular Microbiology, and Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA.
Chen RE; Departments of Internal Medicine, Molecular Microbiology, and Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA.
Gounder AP; Departments of Internal Medicine, Molecular Microbiology, and Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA.
Pinto AK; Departments of Internal Medicine, Molecular Microbiology, and Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA.
Bricker T; Departments of Internal Medicine, Molecular Microbiology, and Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA.
Linton CN; Departments of Internal Medicine, Molecular Microbiology, and Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA.
Rogers CD; Department of Infectious Diseases, St. Jude Children×³s Research Hospital, Memphis, TN 38105, USA.
Williams GD; Departments of Internal Medicine, Molecular Microbiology, and Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA.
Webby RJ; Department of Infectious Diseases, St. Jude Children×³s Research Hospital, Memphis, TN 38105, USA.
Boon AC; Departments of Internal Medicine, Molecular Microbiology, and Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA. Electronic address: jboon@dom.wustl.edu.

Virology ; 494: 89-99, 2016 07.

Article em En | MEDLINE | ID: mdl-27105450

Assuntos

Vírus da Influenza A Subtipo H7N3/genética; Vírus da Influenza A Subtipo H7N3/patogenicidade; Infecções por Orthomyxoviridae/virologia; RNA Polimerase Dependente de RNA/genética; Proteínas Virais/genética; Sequência de Aminoácidos; Aminoácidos; Animais; Sequência Conservada; Subtipo H7N9 do Vírus da Influenza A/genética; Subtipo H7N9 do Vírus da Influenza A/patogenicidade; Camundongos; Camundongos Endogâmicos DBA; Infecções por Orthomyxoviridae/mortalidade; RNA Polimerase Dependente de RNA/química; Vírus Reordenados/genética; Vírus Reordenados/patogenicidade; Índice de Gravidade de Doença; Carga Viral; Proteínas Virais/química; Fatores de Virulência/genética; Replicação Viral

Palavras-chave

Avian influenza virus; DBA/2J; H7 subtype; Pathogenesis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Virais / RNA Polimerase Dependente de RNA / Infecções por Orthomyxoviridae / Vírus da Influenza A Subtipo H7N3 Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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