Organization and dynamics of the actin cytoskeleton during dendritic spine morphological remodeling.
Cell Mol Life Sci
; 73(16): 3053-73, 2016 08.
Article
em En
| MEDLINE
| ID: mdl-27105623
ABSTRACT
In the central nervous system, most excitatory post-synapses are small subcellular structures called dendritic spines. Their structure and morphological remodeling are tightly coupled to changes in synaptic transmission. The F-actin cytoskeleton is the main driving force of dendritic spine remodeling and sustains synaptic plasticity. It is therefore essential to understand how changes in synaptic transmission can regulate the organization and dynamics of actin binding proteins (ABPs). In this review, we will provide a detailed description of the organization and dynamics of F-actin and ABPs in dendritic spines and will discuss the current models explaining how the actin cytoskeleton sustains both structural and functional synaptic plasticity.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Citoesqueleto de Actina
/
Actinas
/
Espinhas Dendríticas
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Proteínas dos Microfilamentos
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Plasticidade Neuronal
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article